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Nootropic Activity of Prospekta in a Blind Placebo-Controlled Study in a Model of Focal Cerebral Ischemia in Rats

  • PHARMACOLOGY AND TOXICOLOGY
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Analysis of the pharmacological activity of the original drug Prospekta in a rat model of focal cerebral ischemia revealed its nootropic effect: course treatment in the post-ischemic period led to recovery of the neurological status of animals at the peak of neurological deficit. Evaluation of the therapeutic potential of the drug in morphological and functional CNS disorders allowed us to conclude that it is advisable to carry out further studies of its biological activity at the preclinical stage (the results obtained in animals were successfully confirmed in a clinical trial of drug efficacy in the treatment of moderate cognitive disorders in the early recovery period after ischemic stroke). Studies of the nootropic activity in other pathologies of the nervous system are also promising.

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Authors and Affiliations

  1. Research Institute of General Pathology and Pathophysiology, Moscow, Russia

    E. V. Kardash, N. V. Petrova, S. A. Tarasov & O. I. Epstein

  2. LLC “MATERIA MEDICA HOLDING”, Moscow, Russia

    E. V. Kardash, N. V. Petrova, G. R. Khakimova, S. A. Tarasov & O. I. Epstein

  3. Porsolt and Partners Pharmacology, Le Genest-Saint-Isle, France

    G. Peyon & E. Esneault

Authors
  1. E. V. Kardash
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  2. N. V. Petrova
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  3. G. R. Khakimova
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  4. S. A. Tarasov
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  5. O. I. Epstein
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  6. G. Peyon
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  7. E. Esneault
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Correspondence to E. V. Kardash.

Additional information

Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 174, No. 10, pp. 439-444, October, 2022

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Kardash, E.V., Petrova, N.V., Khakimova, G.R. et al. Nootropic Activity of Prospekta in a Blind Placebo-Controlled Study in a Model of Focal Cerebral Ischemia in Rats. Bull Exp Biol Med 174, 435–439 (2023). https://doi.org/10.1007/s10517-023-05724-2

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  • DOI: https://doi.org/10.1007/s10517-023-05724-2

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