The cell composition of leukocyte infiltrates in the endometrium, myometrium, and vaginal walls was studied in Wistar rats with modeled chronic endomyometritis after administration of IFNγ (0.1 μg/100 g body weight) in different daily regimens (10.00 or 20.00). Morning injections of this cytokine ameliorated inflammatory infiltration of the uterine wall and vagina, but increased the content of neutrophils in the endometrium. Evening cytokine injections reduced neutrophilic infiltration, enhanced mononuclear infiltration, and had no effect on plasmacytic infiltration of the uterine and vaginal walls. In the vaginal wall, both IFNγ administration schedules decreased neutrophil content. The data indicate the necessity to take into account the circadian rhythms in IFN therapy.
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References
Borzanova MV, Alpenidze DN, Gorelysheva NE. A review of the effectiveness of interferon alfa-2b preparations with intranasal use. Russ. Med. Zh. 2012;20(24):1208-1210. Russian.
Dukhin AO, Luybeshkina VA, Taraskina EV. Chronic pelvic inflammatory disease: controversial issues. Vestn. Ross. Univer. Dryzhby Narodov. Ser.: Meditsina. 2013;(S5):201-209. Russian.
Kotelnikov AV, Kotelnikova SV. The characteristic of the reproductive cycle of white rats at different stages of ontogeny after injecting vitamin E. Vestn. Astrakhan. Gos. Tekh. Univer. 2005;(3):215-218. Russian.
Litvinenko GI, Shurlygina AV, Dergacheva TI, Mel’nikova EV, Verbitskaya LV, Krechetova EV, Trufakin VA. Chronotherapeutic regimen of ridostin for the correction of immune status disorders in patients with chronic non-specific inflammatory gynecological diseases. Ross. Vestn. Akush.-Ginekol. 2004;4(6):12-15. Russian.
Luss LV, Malinovskaya VV, Vyzhkiva EN. Interferons in combination therapy and prophylaxis of influenza and respiratory infections. Effekt. Farmakoter. 2014;(5):14-19. Russian.
Koroleva EG, Dergacheva TI, Shurlygina AV, Poveshchenko OV, Krasil’nikov SE, Konenkov VI. Effect of Bone Marrow Multipotent Mesenchymal Stromal Cells on Blood and Lymphatic Vasculature in Uterine Wall of Wistar Rats during Experimental Chronic Metroendometritis. Bull. Exp. Biol. Med. 2018;165(2):205-208. https://doi.org/10.1007/s10517-018-4130-x
Shurlygina AV, Dergacheva TI, Kovshik IG, Starkova EV, Panteleeva NG, Abdalova AM, Trufakin VA. Influence of various daily modes of introduction gamma-interferon on cellular structure lymphoid organs of female rats with an experimental chronic inflammation of internal genitals. Byull. Sib. Otdel. Ross. Akad. Med. Nauk. 2008;28(5):61-66. Russian.
Arjona A, Boyadjieva N, Sarkar DK. Circadian rhythms of granzyme B, perforin, IFN-gamma, and NK cell cytolytic activity in the spleen: effects of chronic ethanol. J. Immunol. 2004;172(5):2811-2817.
Hriscu ML. Modulatory factors of circadian phagocytic activity. Ann. NY Acad. Sci. 2005;1057:403-430.
Jaiyeoba O, Lazenby G, Soper DE. Recommendations and rationale for the treatment of pelvic inflammatory disease. Expert Rev. Anti Infect. Ther. 2011;9(1):61-70. https://doi.org/10.1586/eri.10.156
Koyanagi S, Suyama H, Kuramoto Y, Matsunaga N, Takane H, Soeda S, Shimeno H, Higuchi S, Ohdo S. Glucocorticoid regulation of 24-hour oscillation in interferon receptor gene expression in mouse liver. Endocrinology. 2006;147(11):5034-5040.
Vishwas DK, Haldar C. MT1 receptor expression and AA-NAT activity in lymphatic tissue following melatonin administration in male golden hamster. Int. Immunopharmacol. 2014;22(1):258-265. https://doi.org/10.1016/j.intimp.2014.06.038
Wever R. Zum Einfluß der Dämmerung auf die circadiane Periodik. Zeitschrift für vergleichende Physiologie. 1967;55(3):255-277.
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Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 169, No. 4, pp. 504-508, April, 2020
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Dergacheva, T.I., Shurlygina, A.V., Abdalova, A.M. et al. Comparative Assessment of Leukocyte Infiltrate Composition in the Uterine and Vaginal Tissues in Rats with Experimental Endomyometritis Treated with Interferon-γ at Different Times of the Day. Bull Exp Biol Med 169, 516–520 (2020). https://doi.org/10.1007/s10517-020-04921-7
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DOI: https://doi.org/10.1007/s10517-020-04921-7