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Ultrastructural Organization of Uveal Melanoma Stromal Cells

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Bulletin of Experimental Biology and Medicine Aims and scope

Typical blood capillaries and vessels in uveal melanoma were shown and different types of uveal melanoma stromal cells were determined by electron microscopy and immunohistochemical analysis. Macrophages, fibroblasts of varying degrees of differentiation and endothelial-like cells with numerous caveolae in the cytoplasm were found in the channels of the extracellular matrix surrounding accumulations of tumor cells. The presence local structures positively stained for markers of the blood and lymphatic vessels (CD31 and podoplanin) in channels of the extracellular matrix suggests that the described endothelial-like cells can be the structural basis for blood and lymphatic vessels of the tumor.

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Authors and Affiliations

  1. Research Institute of Clinical and Experimental Lymphology, Affiliated Branch of the Federal Research Center Institute of Cytology and Genetics, Siberian Division of the Russian Academy of Sciences, Novosibirsk, Russia

    N. P. Bgatova, V. V. Makarova, Yu. S. Taskaeva & S. R. Nogovitsina

  2. S. N. Fyodorov Federal State Institution National Medical Research Center Intersectoral Research and Technology Complex “Eye Microsurgery” Ministry of Health of the Russian Federation, Novosibirsk Branch, Novosibirsk, Russia

    I. A. Toporkov, A. V. Eremina, A. N. Trunov & V. V. Chernykh

Authors
  1. N. P. Bgatova
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  2. V. V. Makarova
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  3. Yu. S. Taskaeva
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  4. S. R. Nogovitsina
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  5. I. A. Toporkov
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  6. A. V. Eremina
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  7. A. N. Trunov
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  8. V. V. Chernykh
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Corresponding author

Correspondence to N. P. Bgatova.

Additional information

Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol, 168, No, 8, pp, 243-249, August, 2019

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Bgatova, N.P., Makarova, V.V., Taskaeva, Y.S. et al. Ultrastructural Organization of Uveal Melanoma Stromal Cells. Bull Exp Biol Med 168, 285–290 (2019). https://doi.org/10.1007/s10517-019-04692-w

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  • DOI: https://doi.org/10.1007/s10517-019-04692-w

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