Skip to main content
SpringerLink
Log in

Blood Serum Levels of Proinflammatory Cytokines (IL-1β, IL-6, TNFα, IL-8, IL-12p70, and IFNγ) in Patients with Uterine Myoma

  • Published:
Bulletin of Experimental Biology and Medicine Aims and scope

We analyzed cytokine profile in blood serum of patients with uterine myoma and revealed significantly reduced level of IFNγ and a tendency towards a decrease in the levels of IL-1β and TNFα; the levels of IL-6, IL-8, and IL-12p70 did not differ from those in healthy women. The drop in the concentrations of factors responsible for inflammation and angiogenesis in tissues are unfavorable for proliferation and differentiation of the uterine tissues.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. Voronin DN, Litsova AO. The local immune response in women with leiomyomas of different types and rates of growth. Ross. Immunol. Zh. 2014;8(1):73-78. Russian.

    Google Scholar 

  2. Ovakimyan AS, Krechetova LV, Vtorushina VV, Vanko LV, Kozachenko IF, Adamyan LV. Plasma and peritoneal fluid IL-1β, IL-8, and substance P levels in patients with different forms of external genital endometriosis and chronic pelvic pain. Akush. Ginekol. 2015;(3):79-86. Russian.

    Google Scholar 

  3. Sosnina AE, Sotnikova NYu, Antsiferova YuS, Boiko OM, Malyshkina AI, Petetyatko LP. The role of IL-8 in the pathogenesis of rapid growth of uterine leiomyoma. Byull. Sib. Otdel. Ross. Akad. Med. Nauk. 2008;28(Suppl. 1):64-68. Russian.

    Google Scholar 

  4. Sosnina AE, Sotnikova NYu, Antsiferova YuS, Boiko OM, Malyshkina AI, Petetyatko LP. The relationship of the cytokine profile of phagocytic cells in uterine myoma with the rate and type of tumor growth. Med. Immunol. 2007;9(2-3):263-264. Russian.

    Google Scholar 

  5. Shramko SV, Zorina VN, Bazhenova LG, Zorina RM, Ryabicheva TG, Chevychalova EV, Zorin NA. Regulatory transport proteins and cytokines in the blood of patients with proliferative diseases of the uterus. Akush. Ginekol. 2016;(5):104-109. Ruusian.

    Article  Google Scholar 

  6. Artis D, Spits H. The biology of innate lymphoid cells. Nature. 2015;517:293-301.

    Article  CAS  Google Scholar 

  7. Biancotto A, Wank A, Perl S, Cook W, Olnes MJ, Dagur PK, Fuchs JC, Langweiler M, Wang E, McCoy JP. Correction: Baseline Levels and Temporal Stability of 27 Multiplexed Serum Cytokine Concentrations in Healthy Subjects. PLoS One. 2015;10(7):e0132870. doi: https://doi.org/10.1371/journal.pone.0132870.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  8. Ciavattini A, Di Giuseppe J, Stortoni P, Montik N, Giannubilo SR, Litta P, Islam MS, Tranquilli AL, Reis FM, Ciarmela P. Uterine fibroids: pathogenesis and interactions with endometrium and endomyometrial junction. Obstet. Gynecol. Int. 2013;2013:173184. doi: https://doi.org/10.1155/2013/173184.

    Article  Google Scholar 

  9. Green DS, Young HA, Valencia JC. Current prospects of type II interferon γ signaling and autoimmunity. J. Biol. Chem. 2017;292(34):13,925-13,933.

    Article  CAS  Google Scholar 

  10. Islam MS, Greco S, Janjusevic M, Ciavattini A, Giannubilo SR, D’Adderio A, Biagini A, Fiorini R, Castellucci M, Ciarmela P. Growth factors and pathogenesis. Best Pract. Res. Clin. Obstet. Gynaecol. 2016;34:25-36.

    Article  Google Scholar 

  11. Kuebler JF, Czech-Schmidt G, Leonhardt J, Ure BM, Petersen C. Type-I but not type-II interferon receptor knockout mice are susceptible to biliary atresia. Pediatr. Res. 2006;59(6):790-794.

    Article  CAS  Google Scholar 

  12. Kurachi O, Matsuo H, Samoto T, Maruo T. Tumor necrosis factor-alpha expression in human uterine leiomyoma and its down-regulation by progesterone. J. Clin. Endocrinol. Metab. 2001;86(5):2275-2280.

    CAS  PubMed  Google Scholar 

  13. Plewka A, Madej P, Plewka D, Kowalczyk A, Miskiewicz A, Wittek P, Leks T, Bilski R. Immunohistochemical localization of selected pro-inflammatory factors in uterine myomas and myometrium in women of various ages. Folia Histochem. Cytobiol. 2013;51(1):73-83.

    Article  CAS  Google Scholar 

  14. Protic O, Toti P, Islam MS, Occhini R, Giannubilo SR, Catherino WH, Cinti S, Petraglia F, Ciavattini A, Castellucci M, Hinz B, Ciarmela P. Possible involvement of inflammatory/reparative processes in the development of uterine fibroids. Cell Tissue Res. 2016;364(2):415-427.

    Article  CAS  Google Scholar 

  15. Seliger B, Ruiz-Cabello F, Garrido F. IFN inducibility of major histocompatibility antigens in tumors. Adv. Cancer Res. 2008;101:249-276.

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Research Institute of Clinical and Experimental Lymphology, Affiliated Branch of Federal Research Center Institute of Cytology and Genetics, Siberian Division of the Russian Academy of Sciences, Novosibirsk, Russia

    V. I. Konenkov, E. G. Koroleva, N. B. Orlov, V. F. Prokof’ev, A. V. Shevchenko, A. M. Novikov & T. I. Dergacheva

Authors
  1. V. I. Konenkov
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. E. G. Koroleva
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. N. B. Orlov
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. V. F. Prokof’ev
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. A. V. Shevchenko
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. A. M. Novikov
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. T. I. Dergacheva
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to T. I. Dergacheva.

Additional information

Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 165, No. 5, pp. 648-652, May 2018

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Konenkov, V.I., Koroleva, E.G., Orlov, N.B. et al. Blood Serum Levels of Proinflammatory Cytokines (IL-1β, IL-6, TNFα, IL-8, IL-12p70, and IFNγ) in Patients with Uterine Myoma. Bull Exp Biol Med 165, 698–701 (2018). https://doi.org/10.1007/s10517-018-4245-0

Download citation

  • Received:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s10517-018-4245-0

Key Words

Search

Navigation