Light microscopy, immunohistochemistry, and morphometric examinations established that cell death in lung granulomas of BCG-infected mice resulted mainly from activation of receptor-mediated apoptosis, which did not prevent the persistence of the causative agent in macrophages of the granulomas and promoted the formation of pronounced fibrosis in granulomas and pulmonary interstitium.
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Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 165, No. 1, pp. 57-61, January, 2018
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Cherdantseva, L.A., Potapova, O.V., Sharkova, T.V. et al. Cell Death and Development of Fibrotic Alterations in Lung Granuloma of BALB/c Mice during Chronic BCG-Induced Granulomatosis. Bull Exp Biol Med 165, 48–51 (2018). https://doi.org/10.1007/s10517-018-4096-8
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DOI: https://doi.org/10.1007/s10517-018-4096-8