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Effect of Chronic Administration of Obestatin and Its Fragment FNAP-NH2 on Behavioral Activity and Nociceptive Threshold in Rats with Normal and Excess Body Weight

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The effects of chronic intranasal administration of 300 nmol/kg obestatin and its fragment FNAP-NH2 on behavioral activity and nociceptive threshold were examined in male Wistar rats with normal body weight or alimentary obesity. In normal rats, obestatin produced no effect on behavior and nociception, whereas FNAP-NH2 fragment enhanced risk-taking behavior. Rats with excess body weight demonstrated less pronounced risk-taking behavior and elevated nociceptive threshold in comparison with normal animals, but these differences were abolished by chronic administration of FNAP-NH2.

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Authors and Affiliations

  1. Department of Human and Animal Physiology, Faculty of Biology, M. V. Lomonosov Moscow State University, Moscow, Russia

    E. E. Khirazova, E. S. Motorykina, M. V. Maslova, A. S. Maklakova, A. V. Graf, N. A. Sokolova & A. A. Kamenskii

  2. Department of Nano-, Bio-, Information Technology, and Cognitive Science, Moscow Institute of Physics and Technology (MIPT), Moscow, Russia

    A. V. Graf

Authors
  1. E. E. Khirazova
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  2. E. S. Motorykina
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  3. M. V. Maslova
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  4. A. S. Maklakova
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  5. A. V. Graf
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  6. N. A. Sokolova
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  7. A. A. Kamenskii
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Corresponding author

Correspondence to E. E. Khirazova.

Additional information

Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 163, No. 3, pp. 268-270, March, 2017

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Khirazova, E.E., Motorykina, E.S., Maslova, M.V. et al. Effect of Chronic Administration of Obestatin and Its Fragment FNAP-NH2 on Behavioral Activity and Nociceptive Threshold in Rats with Normal and Excess Body Weight. Bull Exp Biol Med 163, 293–295 (2017). https://doi.org/10.1007/s10517-017-3787-x

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  • DOI: https://doi.org/10.1007/s10517-017-3787-x

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