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Proliferative and Migration Activity of JEG-3 Trophoblast Cell Line in the Presence of Cytokines

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Bulletin of Experimental Biology and Medicine Aims and scope

TNFα inhibited proliferation and did not inhibit migration JEG-3 trophoblast cells, IL-1β stimulated both cell proliferation and migration, IL-6 and IL-8 stimulated only cell migration, IFNγ has either stimulating or inhibitory effect on proliferation of trophoblast cells depending on its concentration. Cytokines IL-10 and IL-4 stimulated only migration of trophoblast cells. VEGF, PlGF, and TGFβ stimulated both proliferation and migration, and bFGF only migration of trophoblast cells.

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Authors and Affiliations

  1. D. O. Ott Research Institute of Obstetrics and Gynecology, North-Western Division of the Russian Academy of Medical Sciences, St. Petersburg, Russia

    D. I. Sokolov, K. N. Furaeva, O. I. Stepanova & S. A. Sel’kov

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  1. D. I. Sokolov
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  2. K. N. Furaeva
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  3. O. I. Stepanova
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  4. S. A. Sel’kov
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Correspondence to D. I. Sokolov.

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Translated from Kletochnye Tekhnologii v Biologii i Meditsine, No. 2, pp. 95–102, April, 2015

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Sokolov, D.I., Furaeva, K.N., Stepanova, O.I. et al. Proliferative and Migration Activity of JEG-3 Trophoblast Cell Line in the Presence of Cytokines. Bull Exp Biol Med 159, 550–556 (2015). https://doi.org/10.1007/s10517-015-3013-7

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  • DOI: https://doi.org/10.1007/s10517-015-3013-7

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