The antidepressant, psychostimulant, and nootropic effects of a composition of major and trace elements including KCl, RbNO3, magnesium sulfate, and zinc sulfate were studied on the models of behavioural despair (Porsolt test) and conditioned passive avoidance test. The preparation was found to shorten the immobilization time in the Porsolt test and promote retention of the conditioned passive avoidance. The most pronounced psychostimulant effect of the substance was observed at a dose of 4.68 mg/kg and the most pronounced antidepressant effect was found at a dose of 18.72 mg/kg. Maximum nootropic activity of the preparation was found at a dose of 93.6 mg/kg.
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Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 155, No. 2, pp. 167-169, February, 2013
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Afanasieva, O.G., Suslov, N.I. & Shilova, I.V. Antidepressant, Psychostimulant, and Nootropic Effects of Major and Trace Element Composition. Bull Exp Biol Med 155, 204–206 (2013). https://doi.org/10.1007/s10517-013-2113-5
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DOI: https://doi.org/10.1007/s10517-013-2113-5