The relationship between activity of chromosomal nucleolus-organizer regions and levels of chromosome aberrations was studied in 215 residents of the Kursk region by visual semiquantitative method (silver staining of the nucleolus-organizer regions, NOR) in chromosomes of peripheral blood lymphocytes [13]. The levels of chromosome aberrations differed signicantly in three groups differing by the levels of 10AgNOR, which can be explained by different proliferative activity in these groups. The lowest level of chromosome aberrations was found in subjects with high transcription activity of NOR, presumably due to high proliferative activity in this group and more intensive synthesis of proteins, including the reparation enzymes. The highest level of chromosome aberrations was detected in the group with the medium level of 10AgNOR.
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References
N. P. Bochkov, A. N. Chebotarev, and L. D. Katosova, Genetika, No. 4, 549–557 (2001).
N. P. Bochkov, R. Ya. Shram, N. P. Kuleshov, et al., Ibid., 11, 156–169 (1975).
N. P. Dubinin, Yu. P. Altukhov, and O. L. Kurbatova, Dokl. Akad. Nauk SSSR, No. 4, 957–960 (1976).
L. G. Dubinina, Human Blood Leukocytes as a Test System for Evaluation of Environmental Mutagens [in Russian], Moscow (1977).
L. G. Dubinina, Genetika, No. 3, 373–378 (1996).
L. G. Dubinina, Z. I. Kurashova, and I. V. Volkova, Dokl. Akad. Nauk SSSR, 311, No. 2, 481–484 (1990).
O. L. Kurbatova, O. K. Botvinyev, and Yu. P. Altukhov, Genetika, No. 4, 691–697 (1984).
G. F. Lakin, Biometry. Training Aid for Biological Higher School [in Russian], Moscow (1990).
N. A. Lyapunova, N. A. Egolina, and T. G. Tsvetkova, Vestn. Rossiisk. Akad. Med. Nauk, No. 5, 19–23 (2000).
N. A. Lyapunova, I. A. Kravets-Mandron, and T. G. Tsvetkova, Genetika, No. 9, 1298–1306 (1998).
Modern Methods of Chromosome Analysis in Clinical Cytogenetic Studies, Eds. T. A. Zaletaeva et al. [in Russian], Moscow (1994).
V. I. Trubnikov and V. M. Gindilis, Multidimensional Genetic Analysis of Anthropometric Parameters. Communication 1. Genetic Correlation between Signs. Problems of Anthropology [in Russian], Moscow (1980), No. 64, P. 94–106.
W. M. Howell, Chromosome, 62, No. 4, 361–367 (1977).
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Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 149, No. 3, pp. 308–312, March 2010 Original article submitted July 15, 2009
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Medvedev, I.N., Amelina, I.V. Evaluation of the Relationship between Chromosome Aberrations and Transcription Activity of Nucleolus Organizer Regions in Indigenous Population of the Kursk Region. Bull Exp Biol Med 149, 332–336 (2010). https://doi.org/10.1007/s10517-010-0940-1
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DOI: https://doi.org/10.1007/s10517-010-0940-1