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Effect of recombinant interleukin-5, interleukin-3, and eotaxin on apoptosis in eosinophilic granulocytes

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Abstract

We studied in vitro effects of recombinant interleukin-5, interleukin-3, and eotaxin on programmed death of eosinophils from healthy donors and patients with non-Hodgkin’s lymphomas associated with severe blood eosinophilia. Interleukin-5 and eotaxin produced the most potent antiapoptotic effect on eosinophils from healthy donors. In patients with non-Hodgkin’s lymphomas, spontaneous apoptosis in eosinophilic leukocytes was low and remained unchanged during incubation with recombinant proteins.

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Authors and Affiliations

  1. Department of Pathophysiology, Siberian State Medical University, Tomsk

    N. V. Ryazantseva, V. V. Novitskii, L. S. Litvinova, Yu. V. Kolobovnikova, O. B. Zhukova, E. S. Grigor’eva, E. V. Suvorova, E. N. Knutareva, T. T. Radzivil & N. Yu. Chasovskikh

  2. Department for Fundamental Bases of Clinical Medicine, Siberian State Medical University, Tomsk

    N. V. Ryazantseva, V. V. Novitskii, L. S. Litvinova, Yu. V. Kolobovnikova, O. B. Zhukova, E. S. Grigor’eva, E. V. Suvorova, E. N. Knutareva, T. T. Radzivil & N. Yu. Chasovskikh

  3. Federal Agency of Health Care and Social Development, Tomsk

    N. V. Ryazantseva, V. V. Novitskii, L. S. Litvinova, Yu. V. Kolobovnikova, O. B. Zhukova, E. S. Grigor’eva, E. V. Suvorova, E. N. Knutareva, T. T. Radzivil & N. Yu. Chasovskikh

  4. Department of Clinical Physiology and Functional Diagnostics, Russian Medical Academy of Postgraduate Education, Moscow

    S. B. Tkachenko

Authors
  1. N. V. Ryazantseva
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  2. V. V. Novitskii
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  3. L. S. Litvinova
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  4. S. B. Tkachenko
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  5. Yu. V. Kolobovnikova
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  6. O. B. Zhukova
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  7. E. S. Grigor’eva
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  8. E. V. Suvorova
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  9. E. N. Knutareva
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  10. T. T. Radzivil
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  11. N. Yu. Chasovskikh
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Corresponding author

Correspondence to L. S. Litvinova.

Additional information

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Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 143, No. 4, pp. 370–373, April, 2007

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Ryazantseva, N.V., Novitskii, V.V., Litvinova, L.S. et al. Effect of recombinant interleukin-5, interleukin-3, and eotaxin on apoptosis in eosinophilic granulocytes. Bull Exp Biol Med 143, 395–398 (2007). https://doi.org/10.1007/s10517-007-0139-2

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  • DOI: https://doi.org/10.1007/s10517-007-0139-2

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