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Biological activity of hemoglobin-containing complex isolated from blood serum of mice with Ehrlich carcinoma

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Abstract

Injection of hemoglobin-containing complex of serum proteins isolated from animals with Ehrlich carcinoma led to regression of intraperitoneally and intramuscularly transplanted Ehrlich carcinoma in male C57Bl/6 mice. The hemoglobin-containing complex of serum proteins disturbed cycle distribution of Ehrlich carcinoma cells and caused apoptosis of about 34.3% tumor cells. Addition of hemoglobin-containing serum protein complex into Ehrlich carcinoma incubation medium did not lead to the death of tumor cells and even slightly increased their proliferation.

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Authors and Affiliations

  1. N. N. Blokhin Cancer Research Center, Russian Academy of Medical Sciences, Moscow

    F. V. Donenko, S. M. Sitdikova, B. S. Amandzholov & M. V. Kiselevskii

Authors
  1. F. V. Donenko
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  2. S. M. Sitdikova
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  3. B. S. Amandzholov
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  4. M. V. Kiselevskii
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Correspondence to F. V. Donenko.

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Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 142, No. 9, pp. 319–322, September, 2006

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Donenko, F.V., Sitdikova, S.M., Amandzholov, B.S. et al. Biological activity of hemoglobin-containing complex isolated from blood serum of mice with Ehrlich carcinoma. Bull Exp Biol Med 142, 347–350 (2006). https://doi.org/10.1007/s10517-006-0363-1

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  • DOI: https://doi.org/10.1007/s10517-006-0363-1

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