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Effect of pyrrolidone-pyroglutamic acid composition on blood flow in rat middle cerebral artery

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Abstract

We compared the effects of a pyrrolidone-pyroglutamic acid composition and nimodipine on blood circulation in the middle cerebral artery in rats. The composition produced a strong effect on blood supply to the brain, stimulated blood flow in the middle cerebral artery (by 60±9%) and decreased blood pressure (by 25.0±2.7%). The cerebrovascular effects of this composition differed from those of nimodipine. Nimodipine not only increased middle cerebral artery blood flow, but also decreased cerebral blood flow in the early period after treatment.

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References

  1. E. V. Lun’shina, T. S. Gan’shina, and R. S. Mirzoyan, Eksp. Klin. Farmakol., 65, No. 3, 3–5 (2002).

    CAS  PubMed  Google Scholar 

  2. D. D. Matsievskii, Byull. Eksp. Biol. Med., 136, No. 7, 115–118 (2003).

    Google Scholar 

  3. R. S. Mirzoyan, Eksp. Klin. Farmakol., 66, No. 2, 53–56 (2003).

    CAS  Google Scholar 

  4. R. S. Mirzoyan, G. A. Semkina, and D. D. Matsievskii, Byull. Eksp. Biol. Med., 118, No. 10, 410–413 (1994).

    CAS  Google Scholar 

  5. A. V. Topchyan, R. S. Mirzoyan, M. G. Balasanyan, et al., Eur. J. Pharm. Sci., 11,Suppl. 1, S117–S118 (2000).

    Google Scholar 

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Authors and Affiliations

  1. Laboratory for Pharmacology of Cerebrovascular Disorders, V. V. Zakusov Institute of Pharmacology, Russian Academy of Medical Sciences, Moscow

    G. A. Semkina, D. D. Matsievskii & N. R. Mirzoyan

Authors
  1. G. A. Semkina
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  2. D. D. Matsievskii
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  3. N. R. Mirzoyan
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Correspondence to N. R. Mirzoyan.

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Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 141, No. 1, pp. 56–58, January, 2006

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Semkina, G.A., Matsievskii, D.D. & Mirzoyan, N.R. Effect of pyrrolidone-pyroglutamic acid composition on blood flow in rat middle cerebral artery. Bull Exp Biol Med 141, 51–52 (2006). https://doi.org/10.1007/s10517-006-0091-6

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  • DOI: https://doi.org/10.1007/s10517-006-0091-6

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