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Time Course of Cell Proliferation in Rat Liver in the Early Postnatal Ontogeny and Role of Epidermal Growth Factor in Organization of Proliferative Regimen

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Abstract

sCircadian rhythm of DNA synthesis, mitotic activity, and duration of mitosis in rat liver were studied on days 3, 7, and 12 of life. Age-associated differences in the rhythmic parameters of these characteristics were detected. Epidermal growth factor plays an important role in the formation of cell proliferation rhythm in the early postnatal ontogeny and in the formation of proliferative hepatocyte pool.

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Authors and Affiliations

  1. Russian State Medical University, Moscow, Russia

    V. B. Zakharov, S. N. Smirnov, S. G. Mamontov & E. T. Zakharova

Authors
  1. V. B. Zakharov
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  2. S. N. Smirnov
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  3. S. G. Mamontov
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  4. E. T. Zakharova
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Correspondence to V. B. Zakharov.

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Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 139, No. 5, pp. 585–588, May, 2005

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Zakharov, V.B., Smirnov, S.N., Mamontov, S.G. et al. Time Course of Cell Proliferation in Rat Liver in the Early Postnatal Ontogeny and Role of Epidermal Growth Factor in Organization of Proliferative Regimen. Bull Exp Biol Med 139, 622–625 (2005). https://doi.org/10.1007/s10517-005-0361-8

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  • DOI: https://doi.org/10.1007/s10517-005-0361-8

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