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Structural analyses of death domains and their interactions

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Abstract

The death domain (DD), which is a versatle protein interaction module, is the prime mediator of the interactions necessary for apoptosis, innate immunity and the necrosis signaling pathway. Because DD mediated signaling events are associated with critical human diseases, studies in these areas are of great biological importance. Accordingly, many biochemical and structural studies of DD have been conducted in the past decade to investigate apoptotic and innate immune signaling. Evaluation of the molecular structure of DD and their interactions with partners have shown the underlying molecular basis for the assembly of DD mediated complexes and for the regulation of apoptosis and innate immunity. This review summarizes the structure and function of various DDs and DD:DD complexes involved in those signaling pathways.

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Acknowledgments

This research was supported by Basic Science Research Program through the National Research Foundation of Korea (NRF) funded by the ministry of Education, Science and Technology (2010-0020962).

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  1. School of Biotechnology and Graduate School of Biochemistry at Yeungnam University, Gyeongsan, South Korea

    Hyun Ho Park

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Park, H.H. Structural analyses of death domains and their interactions. Apoptosis 16, 209–220 (2011). https://doi.org/10.1007/s10495-010-0571-z

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