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Ceramide induces apoptosis via a peroxisome proliferator-activated receptor γ-dependent pathway

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Abstract

Both of ceramide and PPARγ ligand can trigger cancer cell apoptosis. We here show that C2-ceramide can modulate PPARγ expression level and its transcriptional activity and results in apoptosis in HT29 cells. Administration of PPARγ specific antagonist GW9662 partially prevents HT29 cells from apoptosis. Furthermore, MAP kinase pathway provided a potential modulation mechanism for PPARγ pathway related with ceramide. Our results are the first to demonstrate that C2-ceramide induces apoptosis via a PPARγ-dependent pathway.

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Authors and Affiliations

  1. College of Life Science, Peking University, Beijing, China

    Jing Wang

  2. College of Food Science and Nutritional Engineering, China Agricultural University, Beijing, China

    Jing Wang, Jieping Shi & Xiaosong Hu

  3. Research Center for Eco-Environmental Sciences, The Chinese Academy of Sciences, Beijing, China

    Jing Wang

  4. Feed Research Institute, Chinese Academy of Agricultural Sciences, Beijing, China

    Xiaowen Lv

Authors
  1. Jing Wang
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  2. Xiaowen Lv
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  3. Jieping Shi
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  4. Xiaosong Hu
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Corresponding author

Correspondence to Jing Wang.

Additional information

J. Wang and X. Lv contributed equally to this work.

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Wang, J., Lv, X., Shi, J. et al. Ceramide induces apoptosis via a peroxisome proliferator-activated receptor γ-dependent pathway. Apoptosis 11, 2043–2052 (2006). https://doi.org/10.1007/s10495-006-0191-9

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  • DOI: https://doi.org/10.1007/s10495-006-0191-9

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