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Wearable Water Content Sensor Based on Ultrasound and Magnetic Sensing

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Abstract

Fluid accumulation in the lower extremities is an early indicator of disease deterioration in cardiac failure, chronic venous insufficiency and lymphedema. At-home wearable monitoring and early detection of fluid accumulation can potentially lead to prompt medical intervention and avoidance of hospitalization. Current methods of fluid accumulation monitoring either suffer from lack of specificity and sensitivity or are invasive and cost-prohibitive to use on a daily basis. Ultrasound velocity in animal and human tissue has been found to change with water content. However, previous prototype fluid monitoring sensors based on ultrasound are cumbersome and not wearable. Hence, in this research a compact water content sensor based on a wearable instrumented elastic band is proposed. A novel integration of magnetic sensing and ultrasonic sensing is utilized, where the magnetic sensor provides distance measurement and the ultrasonic sensor produces time-of-flight measurement. Magnetic field modeling with a Kalman filter and least squares linear fitting algorithms are employed to ensure robust sensor performance on a wearable device. The combination of the two measurements yields ultrasound velocity measurement in tissue. The water content sensor prototype was tested on a tissue phantom, on animal tissue and on a human leg. The error in velocity measurement is shown to be small enough for early detection of tissue edema.

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References

  1. Abraham, W. T., et al. Intrathoracic impedance vs daily weight monitoring for predicting worsening heart failure events: results of the fluid accumulation status trial (FAST). Congest. Hear. Fail. 17:51–55, 2011.

    Article  Google Scholar 

  2. Azhari, H. Basics of Biomedical Ultrasound for Engineers. New York: Wiley, 2010. https://doi.org/10.1002/9780470561478.

    Book  Google Scholar 

  3. Brodowicz, K. G., et al. Reliability and feasibility of methods to quantitatively assess peripheral edema. Clin. Med. Res. 7:21–31, 2009.

    Article  Google Scholar 

  4. Bui, A. L., and G. C. Fonarow. Home monitoring for heart failure management. J. Am. Coll. Cardiol. 59:97–104, 2012.

    Article  PubMed  PubMed Central  Google Scholar 

  5. Cho, S., and J. E. Atwood. Peripheral edema. Am. J. Med. 113:580–586, 2002.

    Article  PubMed  Google Scholar 

  6. Cleveland Clinic. Heart Failure: Monitoring Your Weight & Fluid Intake. 2016. https://my.clevelandclinic.org/health/diseases/17243-heart-failure-monitoring-your-weight–fluid-intake. Accessed on 6 February 2018.

  7. Cobbold, R. S. C. Foundations of Biomedical Ultrasound. Oxford: Oxford University Press, 2007.

    Google Scholar 

  8. Gu, M. D. Investigating a relationship between speed of sound and hydrogel water content via ultrasound for future articular cartilage applications. Cleveland, OH: Case Western Reserve University, p. 2013, 2013.

    Google Scholar 

  9. Guex, J. J., and M. Perrin. Edema and leg volume: methods of assessment. Angiology 51:9–12, 2000.

    Article  PubMed  Google Scholar 

  10. Harvard Health. Fluid Retention: What it can Mean for Your Heart. 2014. https://www.health.harvard.edu/heart-health/fluid-retention-what-it-can-mean-for-your-heart. Accessed on 6 February 2018

  11. Harvard University. A summary of error propagation. Phys. Sci. 2:5, 2007.

    Google Scholar 

  12. Ida, N. Engineering Electromagnetics. Berlin: Springer, 2015. https://doi.org/10.1007/978-3-319-07806-9.

    Book  Google Scholar 

  13. Inan, U. S., and A. S. Inan. Engineering Electromagnetics. Menlo Park: Addison-Wesley, 1999.

    Google Scholar 

  14. Kataoka, H. Clinical significance of bilateral leg edema and added value of monitoring weight gain during follow-up of patients with established heart failure. ESC Hear. Fail. 2015. https://doi.org/10.1002/ehf2.12043.

    Article  Google Scholar 

  15. Kumarasinghe, G., and G. Carroll. A guide to peripheral oedema. Med. Today 16:26–34, 2015.

    Google Scholar 

  16. Maines, M., D. Catanzariti, C. Cemin, C. Vaccarini, and G. Vergara. Usefulness of intrathoracic fluids accumulation monitoring with an implantable biventricular defibrillator in reducing hospitalizations in patients with heart failure: a case-control study. J. Interv. Card. Electrophysiol. 19:201–207, 2007.

    Article  PubMed  Google Scholar 

  17. Marshburn, T., R. Cole, J. Pavela, K. Garcia and A. Sargsyan. Facial Soft Tissue Measurement in Microgravity-Induces Fluid Shifts, 2014.

  18. McDonald, K. Monitoring fluid status at the outpatient level: the need for more precision. Congest. Hear. Fail. 16:52–55, 2010.

    Article  Google Scholar 

  19. Mcskimin, H. J. Velocity of sound in distilled water for the temperature range 20°–75°. C. J. Acoust. Soc. Am. 37:325–328, 1965.

    Article  Google Scholar 

  20. Micheau, A. and D. Hoa. Lower extremity: MRI of anatomical atlas. e-Anatomy, 2017. https://www.imaios.com/en/e-Anatomy/Limbs/Lower-extremity-MRI. Accessed on 20th June 2018.

  21. Nieman, D. C., R. A. Shanely, K. A. Zwetsloot, M. P. Meaney, and G. E. Farris. Ultrasonic assessment of exercise-induced change in skeletal muscle glycogen content. BMC Sports Sci. Med. Rehabil. 7:1–7, 2015.

    Article  Google Scholar 

  22. Noble, V. E., et al. Ultrasound assessment for extravascular lung water in patients undergoing hemodialysis: time course for resolution. Chest 135:1433–1439, 2009.

    Article  Google Scholar 

  23. Onda Corporation. Acoustic Properties of Rubbers. Sunnyvale, CA: Onda Corporation, 2003.

    Google Scholar 

  24. Paulev, P.-E. Textbook in medical physiology and pathophysiology. Copenhagen: Copenhagen Medical Publishers, 1999.

    Google Scholar 

  25. Physics Stack Exchange. What is the Strength of the Magnetic Field Required to Penetrate an Average Human Body? 2017. http://physics.stackexchange.com/questions/194312/what-is-the-strength-of-the-magnetic-field-required-to-penetrate-an-average-huma. Accessed on 6th February 2018.

  26. Physics Stack Exchange. From What Wavelength can Radiation go Through a Human Body Without Very Much Changing? 2017. https://physics.stackexchange.com/questions/239494/from-what-wavelength-can-radiation-go-through-a-human-body-without-very-much-cha. Accessed on 6th February 2018.

  27. Routson, M. Why it is important to use gel in ultrasound. HubPages, 2016. https://hubpages.com/education/aquasonic_ultrasound_gel. Accessed on 6th February 2018.

  28. Sarvazyan, A., A. Tatarinov, and N. Sarvazyan. Ultrasonic assessment of tissue hydration status. Ultrasonics 43:661–671, 2005.

    Article  PubMed  Google Scholar 

  29. Sarvazyan, A. P., S. N. Tsyuryupa, M. Calhoun, and A. Utter. Acoustical method of whole body hydration status monitoring. Acoust. Phys. 62:514–522, 2016.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  30. Selfridge, A. R. Approximate material properties in isotropic materials. IEEE Trans. Sonics Ultrason. 32:381–394, 1985.

    Article  Google Scholar 

  31. Simon, D. Optimal State Estimation: Kalman, H∞, and Nonlinear Approaches. New York: Wiley, 2006. https://doi.org/10.1002/0470045345.

    Book  Google Scholar 

  32. Teerlink, J. R., K. Alburikan, M. Metra, and J. E. Rodgers. Acute decompensated heart failure update. Curr. Cardiol. Rev. 11:53–62, 2015.

    Article  PubMed  PubMed Central  Google Scholar 

  33. Topchyan, A., A. Tatarinov, N. Sarvazyan, and A. Sarvazyan. Ultrasound velocity in human muscle in vivo: perspective for edema studies. Ultrasonics 44:259–264, 2006.

    Article  PubMed  Google Scholar 

  34. Trayes, K. P., J. S. Studdiford, S. Pickle, and A. S. Tully. Edema: diagnosis and management. Am. Fam. Physician 88:102–110, 2013.

    PubMed  Google Scholar 

  35. Ulaby, F. T., and U. Ravaioli. Fundamentals of Applied Electromagnetics. Upper Saddle River, NJ: Pearson, 2015.

    Google Scholar 

  36. Zhang, S., and R. Rajamani. Modeling of magnetic fields on a cylindrical surface and associated parameter estimation for development of a size sensor. Meas Sci Technol 2016. https://doi.org/10.1088/0957-0233/27/11/115006.

    Article  PubMed  PubMed Central  Google Scholar 

  37. Zhang, S., R. Rajamani, L. Alexander, and A. Serdar Sezen. Note: development of leg size sensors for fluid accumulation monitoring. Rev. Sci. Instrum. 87:1–4, 2016.

    Google Scholar 

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Acknowledgments

This work was partly supported by funds from the National Science Foundation, Division of Information & Intelligent Systems, Grant IIS-1231582, and by the Minnesota Partnership for Biotechnology and Medical Genomics.

Conflict of interest

A portion of the work reported in this paper has been protected through a patent filing. The pending patent will belong to the University of Minnesota and not to the authors of this paper. The authors have no conflict of interest in presenting these results for publication.

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Authors and Affiliations

  1. Department of Mechanical Engineering, University of Minnesota, Minneapolis, MN, USA

    Song Zhang, Rajesh Rajamani & A. Serdar Sezen

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  1. Song Zhang
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  2. Rajesh Rajamani
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  3. A. Serdar Sezen
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Corresponding author

Correspondence to Rajesh Rajamani.

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Associate Editor Tingrui Pan oversaw the review of this article.

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Zhang, S., Rajamani, R. & Sezen, A.S. Wearable Water Content Sensor Based on Ultrasound and Magnetic Sensing. Ann Biomed Eng 46, 2079–2090 (2018). https://doi.org/10.1007/s10439-018-02108-w

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  • DOI: https://doi.org/10.1007/s10439-018-02108-w

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