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PEG–Maleimide Hydrogels for Protein and Cell Delivery in Regenerative Medicine

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Abstract

Protein- and cell-based therapies represent highly promising strategies for regenerative medicine, immunotherapy, and oncology. However, these therapies are significantly limited by delivery considerations, particularly in terms of protein stability and dosing kinetics as well as cell survival, engraftment, and function. Hydrogels represent versatile and robust delivery vehicles for proteins and cells due to their high water content that retains protein biological activity, high cytocompatibility and minimal adverse host reactions, flexibility and tunability in terms of chemistry, structure, and polymerization format, ability to incorporate various biomolecules to convey biofunctionality, and opportunity for minimally invasive delivery as injectable carriers. This review highlights recent progress in the engineering of poly(ethylene glycol) hydrogels cross-linked using maleimide reactive groups for protein and cell delivery.

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Acknowledgments

AJG is partially supported by the NIH (R01 AR062368, R01 AR062920, DP3 DK094346), NSF (CBET 0939511) and the Juvenile Diabetes Research Foundation (17-2013-277).

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  1. Woodruff School of Mechanical Engineering, Petit Institute for Bioengineering and Bioscience, Georgia Institute of Technology, Atlanta, GA, USA

    Andrés J. García

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  1. Andrés J. García
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Correspondence to Andrés J. García.

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Associate Editor Robert Nerem oversaw the review of this article.

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García, A.J. PEG–Maleimide Hydrogels for Protein and Cell Delivery in Regenerative Medicine. Ann Biomed Eng 42, 312–322 (2014). https://doi.org/10.1007/s10439-013-0870-y

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  • DOI: https://doi.org/10.1007/s10439-013-0870-y

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