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Human-Urine Diabetes Assay and In Vivo Rat Bladder Assay Using a Fluorine-Doped Carbon Nanotube Catheter Sensor

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Abstract

The creation of a novel biosensor consisting of a fluorine-doped carbon nanotube (FCN) was explored for use in cyclic voltammetric (CV) and square-wave stripping voltammetric (SW) glucose assay. In the experiment that was carried out in this study, analytical optimum conditions were attained at the low detection limit (S/N3) of 0.6 μg/L (3.3 × 10−9 M). In the 0.1 mg/L spike, the relative standard deviation of 0.607 (n = 15) was obtained. This was used for the diagnosis of the urine of patients with diabetes. Moreover, the catheter-type electrode (CE) can be inserted into a rat bladder through the rat’s organs. Thus, it can be connected with an electrochemical analyzer that can be fitted with an interface for the real-time in vivo analysis of metabolic glucose. The developed system can be used for organ treatment, biological analysis, and in vivo control.

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Authors and Affiliations

  1. Biosensor Research Institute, Seoul National University of Technology, 172, Gongreung 2-dong Nowon-gu, Seoul, 139-743, South Korea

    Suw Young Ly

  2. Department of Chemical Engineering, Seoul National University of Technology, Seoul, 139-743, South Korea

    Jin Hui Lee

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  1. Suw Young Ly
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Correspondence to Suw Young Ly.

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Ly, S.Y., Lee, J.H. Human-Urine Diabetes Assay and In Vivo Rat Bladder Assay Using a Fluorine-Doped Carbon Nanotube Catheter Sensor. Ann Biomed Eng 37, 2028–2033 (2009). https://doi.org/10.1007/s10439-009-9714-1

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  • DOI: https://doi.org/10.1007/s10439-009-9714-1

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