Skip to main content
Log in

Modular component design for portable microfluidic devices

  • Short Communication
  • Published:
Microfluidics and Nanofluidics Aims and scope Submit manuscript

Abstract

A new modular design concept for microfluidic devices is proposed and demonstrated in this study. We designed three key modular microfluidic components: pumps, valves, and reservoirs, and demonstrated that a microfluidic device with specific functions can be easily assembled with those key modular components. Our pumps are man-powerable so that the assembled microfluidic devices require no any other power sources like expensive syringe pumps or air compressors. This feature makes the assembled microfluidic devices completely portable. We also combined our assembled device with other existing mixing microchannels to serve as the mixing and loading system in polymerase chain reaction experiment to amplify DNA successfully. This result shows that those modular components can be integrated into other microchannels, implying great potential applications of the modular design.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1
Fig. 2
Fig. 3
Fig. 4
Fig. 5
Fig. 6
Fig. 7
Fig. 8
Fig. 9
Fig. 10

References

  • Abdelgawad M, Watson MWL, Wheeler AR (2009) Hybrid microfluidics: a digital-to-channel interface for in-line sample processing and chemical separations. Lab on a Chip 9:1046–1051

    Article  Google Scholar 

  • Chen HH, Purtteman JJP, Heimfeld S, Folch A, Gao D (2007) Development of a microfluidic device for determination of cell osmotic behavior and membrane transport properties. Cryobiology 55:200–209

    Article  Google Scholar 

  • Davidsson R, Genin F, Bengtsson M, Laurell T, Emneus J (2004) Microfluidic biosensing systems—part I. Development and optimisation of enzymatic chemiluminescent mu-biosensors based on silicon microchips. Lab on a Chip 4:481–487

    Article  Google Scholar 

  • Desmet G, Baron GV (2000) The possibility of generating high-speed shear-driven flows and their potential application in liquid chromatography. Anal Chem 72:2160–2165

    Article  Google Scholar 

  • Duffy DC, Gillis HL, Lin J, Sheppard NF, Kellogg GJ (1999) Microfabricated centrifugal microfluidic systems: characterization and multiple enzymatic assays. Anal Chem 71:4669–4678

    Article  Google Scholar 

  • Escarpa A, Gonzalez MC, Gil MAL, Crevillen AG, Hervas M, Garcia M (2008) Microchips for CE: breakthroughs in real-world food analysis. Electrophoresis 29:4852–4861

    Article  Google Scholar 

  • Fan SK, Huang PW, Wang TT, Peng YH (2008) Cross-scale electric manipulations of cells and droplets by frequency-modulated dielectrophoresis and electrowetting. Lab on a Chip 8:1325–1331

    Article  Google Scholar 

  • Grodzinski P, Yang J, Liu BH, Ward MD (2003) A modular microfluidic system for cell pre-concentration and genetic sample preparation. Biomed Microdevices 5(4):303–310

    Article  Google Scholar 

  • Hofmann O, Niedermann P, Manz A (2001) Modular approach to fabrication of three-dimensional microchannel systems in PDMS—application to sheath flow microchips. Lab on a Chip 1(2):108–114

    Article  Google Scholar 

  • Ito T, Hiroi T, Amaya T, Kaneko S, Araki M, Ohsawa T, Yamamura A, Matsumoto K (2009) Preliminary study of a microbeads based histamine detection for food analysis using thermostable recombinant histamine oxidase from Arthrobacter crystallopoietes KAIT-B-007. Talanta 77:1185–1190

    Article  Google Scholar 

  • Laser DJ, Santiago JG (2004) A review of micropumps. J Micromech Microeng 14:R35–R64

    Article  Google Scholar 

  • McKnight TE, Culbertson CT, Jacobson SC, Ramsey JM (2001) Electroosmotically induced hydraulic pumping with integrated electrodes on microfluidic devices. Anal Chem 73:4045–4049

    Article  Google Scholar 

  • Oh KW, Ahn CH (2006) A review of microvalves. J Micromech Microeng 16:R13–R39

    Article  Google Scholar 

  • Park JY, Hwang CM, Lee SH (2007) Gradient generation by an osmotic pump and the behavior of human mesenchymal stem cells under the fetal bovine serum concentration gradient. Lab on a Chip 7:1673–1680

    Article  Google Scholar 

  • Rhee M, Burns MA (2008) Microfluidic assembly blocks. Lab on a Chip 8(8):1365–1373

    Article  Google Scholar 

  • Shaikh KA, Ryu KS, Goluch ED, Nam JM, Liu J, Thaxton CS, Chiesl TN, Barron AE, Lu Y, Mirkin CA, Liu C (2005) A modular microfluidic architecture for integrated biochemical analysis. PNAS 102(28):9745–9750

    Article  Google Scholar 

  • Tachi T, Kaji N, Tokeshi M, Baba Y (2009) Simultaneous separation, metering, and dilution of plasma from human whole blood in a microfluidic system. Anal Chem 81:3194–3198

    Article  Google Scholar 

  • Tachikawa K, Dittrich PS, Manz A (2009) Microfluidic imaging: a novel concept for pixelation of chemical and biological samples. Sens Actuators B 137:781–788

    Article  Google Scholar 

  • Weng X, Chon CH, Jiang H, Li DQ (2009) Rapid detection of formaldehyde concentration in food on a polydimethylsiloxane (PDMS) microfluidic chip. Food Chem 114:1079–1082

    Article  Google Scholar 

  • Xu H, Shuler HL (2009) Quantification of chemical-polymer surface interactions in microfluidic cell culture devices. Biotechnol Prog 25:543–551

    Article  Google Scholar 

  • Xu ZR, Zhong CH, Guan YX, Chen XW, Wang JH, Fang ZL (2008) A microfluidic flow injection system for DNA assay with fluids driven by an on-chip integrated pump based on capillary and evaporation effects. Lab on a Chip 8:1658–1663

    Article  Google Scholar 

  • Yuen PK, Bliss JT, Thompson CC, Peterson RC (2009) Multidimensional modular microfluidic system. Lab on a Chip 9(22):3303–3305

    Article  Google Scholar 

Download references

Acknowledgment

The authors would like to thank the financial support of the National Science Council of Taiwan, Republic of China under Contract No. NSC96-2628-E-002-197-MY3.

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Ping-Hei Chen.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Liou, DS., Hsieh, YF., Kuo, LS. et al. Modular component design for portable microfluidic devices. Microfluid Nanofluid 10, 465–474 (2011). https://doi.org/10.1007/s10404-010-0681-5

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s10404-010-0681-5

Keywords

Navigation