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Ex vivo evaluation of high-intensity focused ultrasound with ultrasonic-induced cavitation bubbles

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Abstract

Purpose

In high-intensity focused ultrasound (HIFU) comprising high-intensity burst ultrasound (triggering pulse) and medium-intensity continuous wave ultrasound (heating wave), optimizing the effects of the triggering pulse conditions on the coagulated volume may help to reduce treatment times.

Methods

HIFU combined with a triggering pulse was applied to chicken deep pectoral muscles. The acoustic power of the heating wave was set to 36, 54, or 72 W. Four different triggering pulse conditions were used: heating wave only; or pulse widths and pulse repetition frequencies of 30 μs and 1 kHz, 300 μs, and 100 Hz, or 3 ms and 10 Hz.

Results

Compared to the heating wave only condition, the coagulated volume was significantly larger under all conditions that included a triggering pulse. Significant differences were also observed in the ellipticity of the coagulated region between some conditions.

Conclusion

HIFU combined with a triggering pulse may play an important role in reducing treatment times.

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Acknowledgments

We would like to thank Shin Yoshizawa and Shin-ichiro Umemura for assistance with the use of the HIFU transducer. This research was partially supported by the Ministry of Economy, Trade and Industry, Japan (METI, Standardization Promotion Project). A part of this research was supported by a grant from the Japan Society for the Promotion of Science (JSPS) through the “Funding Program for World-Leading Innovative R&D on Science and Technology (FIRST Program),” initiated by the Council for Science and Technology Policy (CSTP).

Conflict of interest

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Authors and Affiliations

  1. Joint Graduate School of Tokyo Women’s Medical University and Waseda University Cooperative Major in Advanced Biomedical Sciences, 8-1 Kawada-cho, Shinjuku-ku, Tokyo, 162-8666, Japan

    Nobutaka Abe & Hiroshi Iseki

  2. Application Development Office, Hitachi Medical Corporation, Chiba, Japan

    Nobutaka Abe & Hidekazu Nakamoto

  3. Faculty of Advanced Techno-Surgery, Institute of Advanced Biomedical Engineering and Science, Tokyo Women’s Medical University, Tokyo, Japan

    Takashi Suzuki, Yoshihiro Muragaki & Hiroshi Iseki

Authors
  1. Nobutaka Abe
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  2. Hidekazu Nakamoto
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  3. Takashi Suzuki
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  4. Yoshihiro Muragaki
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  5. Hiroshi Iseki
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Corresponding author

Correspondence to Nobutaka Abe.

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Abe, N., Nakamoto, H., Suzuki, T. et al. Ex vivo evaluation of high-intensity focused ultrasound with ultrasonic-induced cavitation bubbles. J Med Ultrasonics 41, 3–9 (2014). https://doi.org/10.1007/s10396-013-0469-9

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  • DOI: https://doi.org/10.1007/s10396-013-0469-9

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