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Novel corneal morphological alterations in Vogt-Koyanagi-Harada disease

  • Clinical Investigation
  • Published:
Japanese Journal of Ophthalmology Aims and scope Submit manuscript

Abstract

Purpose

To determine whether visual function, especially when dependent on the anterior segment of ocular tissue, is altered during high-dose steroid treatment for Vogt-Koyanagi-Harada disease (VKH).

Study design

Retrospective case series

Methods

This case series included 18 eyes of 18 patients with VKH who received high-dose steroid therapy as initial treatment. All patients underwent anterior swept-source optical coherent tomography (CASIA-2) examinations during their clinical course to measure the central corneal thickness (CCT), average central corneal power (ACCP), maximum curvature (Kmax) and anterior chamber depth (ACD).

Results

The treatment duration was classified into the initial phase (earliest initial phase eIP; 0–1 month, initial phase: IP; 1–3months), middle phase (MP; 3–6 months), and late phase (LP; 6–9 months). The CCT decreased significantly after treatment (eIP vs. IP, p<0.01, eIP vs. MP, p<0.01; eIP vs. LP, p<0.01). The CCT at eIP was correlated with the flare value at 0M (R2=0.22). The change in Kmax at MP and LP was correlated with the flare value at 0M. Moreover, CCT at MP was correlated with rate of change in nasal angle open distance (AOD) at IP and rate of change in temporal AOD at IP.

Conclusions

This study was the first to reveal morphological changes in the anterior segment of the eye in VKH using CASIA-2, which may affect visual acuity and the astigmatic axis. It is vital to assess corneal morphology to determine the cause of visual function deterioration in patients with VKH.

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Acknowledgments

The professional English editing was performed by Editage (https://www.editage.jp/?medium=ppc&source=rbsp).

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Authors and Affiliations

  1. Department of Ophthalmology, Graduate School of Medicine, Osaka University, Osaka, Japan

    Yuki Hamano, Kazuichi Maruyama, Yoshinori Oie, Shizuka Koh, Noriyasu Hashida & Kohji Nishida

  2. Department of Vision Informatics, Graduate School of Medicine, Osaka University, 2-2 Yamadaoka, Suita, Osaka, 565-0871, Japan

    Kazuichi Maruyama & Naoyuki Maeda

  3. Kozaki Eye Clinic, Osaka, Japan

    Naoyuki Maeda

  4. Department of Innovative Visual Science, Graduate School of Medicine, Osaka University, Osaka, Japan

    Shizuka Koh

  5. Integrated Frontier Research for Medical Science Division, Institute for Open and Transdisciplinary Research Initiatives (OTRI), Osaka University, Osaka, Japan

    Kazuichi Maruyama & Kohji Nishida

Authors
  1. Yuki Hamano
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  2. Kazuichi Maruyama
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  3. Yoshinori Oie
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  4. Naoyuki Maeda
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  5. Shizuka Koh
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  6. Noriyasu Hashida
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  7. Kohji Nishida
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Corresponding author

Correspondence to Kazuichi Maruyama.

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Conflicts of interest

Y. Hamano, None; K. Maruyama, None; Y. Oie, None; N. Maeda, None; S. Koh, None; N. Hashida, None; K. Nishida, None.

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Corresponding Author: Kazuichi Maruyama

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Hamano, Y., Maruyama, K., Oie, Y. et al. Novel corneal morphological alterations in Vogt-Koyanagi-Harada disease. Jpn J Ophthalmol 66, 358–364 (2022). https://doi.org/10.1007/s10384-022-00914-3

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  • DOI: https://doi.org/10.1007/s10384-022-00914-3

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