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Polymorphisms in the VEGF-A in polypoidal choroidal vasculopathy in a Korean population

  • Clinical Investigation
  • Published:
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Abstract

Purpose

The aim of this study was to investigate whether polymorphisms in the vascular endothelial growth factor A gene (VEGF-A) are associated with polypoidal choroidal vasculopathy (PCV) in a Korean population and whether they are associated with PCV phenotypes.

Methods

This was a case–control study comprising 111 patients with PCV and 123 control participants. The PCV and control groups were genotyped for five polymorphisms in VEGF-A. Clinical characteristics were evaluated, including best-corrected visual acuity, fundus findings, and angiography findings at the first visit. Main outcome measures were the genotypes of variants and association with phenotypes.

Results

Only rs833069 in VEGF-A generated significant allelic associations with PCV (P = 2.24 × 10−5). As compared with the AA group, the GG genotype group in rs833069 had a 6.25-fold increased risk of PCV [P = 7.45 × 10−5, 95% confidence interval (CI) 2.52–15.46] and the AG group had a 1.82-fold increased risk (P = 0.029, 95% CI 1.03–3.24). The haplotype CCGC in VEGF-A showed an association with PCV (P = 2.90 × 10−5). However, the phenotypic characteristics of PCV did not show an association with the rs833069 genotypes.

Conclusions

The rs833069 polymorphism in VEGF-A was significantly associated with the risk of PCV in a Korean population.

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Acknowledgments

This work was supported by a Biomedical Research Institute Grant from Kyungpook National University Hospital (2011).

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Authors and Affiliations

  1. Department of Ophthalmology, School of Medicine, Kyungpook National University, #50 Samduk-dong-2-ga, Jung-gu, Daegu, 700-721, South Korea

    Dong Ho Park & In Taek Kim

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  1. Dong Ho Park
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  2. In Taek Kim
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Correspondence to In Taek Kim.

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Park, D.H., Kim, I.T. Polymorphisms in the VEGF-A in polypoidal choroidal vasculopathy in a Korean population. Jpn J Ophthalmol 56, 145–151 (2012). https://doi.org/10.1007/s10384-012-0119-6

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  • DOI: https://doi.org/10.1007/s10384-012-0119-6

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