Abstract
Elaeagnus angustifolia L. is an important plant species that has a wide geographical distribution and is used for both food and medicinal purposes in different cultures. In this review, the areas of use, medicinal properties, biological activities as well as the chemical and phenolic contents of E. angustifolia reported in the literature are examined. Studies show that this plant has been traditionally used in the treatment of different diseases. In particular, it is noteworthy that it can be a natural drug candidate thanks to its antioxidant and antimicrobial activities. It has been determined that many biologically active chemical and phenolic compounds are found in various parts of the plant such as root, leaf, flower and fruit. It has been determined that these compounds have effects such as neutralizing free radicals, providing anti-inflammatory effects and suppressing microbial infections. In addition, studies on the positive effects and pharmacological potential of phenolic substances found in the composition of E. angustifolia on human health further increase the medical importance of this plant. Natural components, especially polyphenols, flavonoids, alkaloids and essential oils, show that this plant can be a promising source in drug development processes. In conclusion, E. angustifolia is a biologically and chemically rich natural source that can be evaluated in a wide range from traditional medicine to modern pharmacological designs. Advanced studies on this plant can make significant contributions to the development of new treatment approaches.
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References
Abri A, Maleki M (2016) Isolation and identification of gallic acid from the Elaeagnus angustifolia leaves and determination of total phenolic, flavonoids contents and investigation of antioxidant activity. Iran Chem Commun 4(2):146–154
Ahmad Z, Özdemir B, Sevindik M, Eraslan EC, Selamoglu Z, Bal C (2023) Phenolic compound and antioxidant potential of Hebeloma sinapizans mushroom. Agrolife Sci J 12(2):12–17. https://doi.org/10.17930/AGL202322
Ahmadiani A, Hosseiny J, Semnanian S, Javan M, Saeedi F, Kamalinejad M, Saremi S (2000) Antinociceptive and anti-inflammatory effects of Elaeagnus angustifolia fruit extract. J Ethnopharmacol 72(1–2):287–292. https://doi.org/10.1016/s0378-8741(00)00222-1
Amini MH, Ahmady A, Zhakfar AM, Sediqi MN, Babak G (2019) Preliminary phytochemical profile, in vitro antioxidant and sun protective activities of Alhagi pseudalhagi and Elaeagnus angustifolia L. J Pharm Res Int 31(4):1–13. https://doi.org/10.9734/jpri/2019/v31i430308
Ayaz FA, Bertoft E (2001) Sugar and phenolic acid composition of stored commercial oleaster fruits. J Food Compos Anal 14(5):505–511. https://doi.org/10.1006/jfca.2001.1004
Aynur R, Nurmamat A, Mehsum H, Kudret H, Nie L (2015) GC-MS analysis of volatile oil in Elaeagnus angustifolia flower extracted by CO2 supercritical fluid. Northwest Pharmaceutical J 30(1):9–14
Baba H, Sevindik M, Dogan M, Akgül H (2020) Antioxidant, antimicrobial activities and heavy metal contents of some Myxomycetes. Fresen Environ Bull 29(09):7840–7846
Badrhadad A, Kh P, Mansouri K (2012) In vitro anti-angiogenic activity fractions from hydroalcoholic extract of Elaeagnus angustifolia L. flower and Nepeta crispa L. arial part. J Med Plant Res 6:4633–4639. https://doi.org/10.5897/JMPR11.1573
Bal C, Sevindik M, Akgul H, Selamoglu Z (2019) Oxidative stress index and antioxidant capacity of Lepista nuda collected from Gaziantep/Turkey. Sigma J Eng Nat Sci 37(1):1–5
Bucur L, Stanciu G, Istudor V (2007) The GC-MS analysis of Elaeagnus angustfolia L. flowers essential oil. Rev Chım Bucharest Orıg Ed 58(11):1027
Bucur L, Negreanu-Pîrjol T, Giurginca M, Istudor V (2008) Some new Elaeagnus angustifolia L. extracts and the pharmaceutical products’ antioxidant activities determined by the chemiluminiscence method. Rev Roum Chim 53:961–964
Bucur L, Vlase L, Istudor V, Popescu A (2009) HPLC-MS analysis of the polyphenols in two soft extracts of Elaeagnus angustifolia L. Note 2. Soft extract of young branches analysis. Farmacia 57(6):736–742
Caliskan E, Elmastas M, Gokce I (2010) Evaluation of antioxidant properties of Elaeagnus angustifolia flowers. Asian J Chem 22(4):2840–2848
Cansev A, Sahan Y, Celik G, Taskesen S, Ozbey H (2011) Chemical properties and antioxidant capacity of Elaeagnus angustifolia L. fruits. Asian J Chem 6(23):2661–2665
Carradori S, Cairone F, Garzoli S, Fabrizi G, Iazzetti A, Giusti AM, Cesa S (2020) Phytocomplex characterization and biological evaluation of powdered fruits and leaves from Elaeagnus angustifolia. Molecules 25(9):2021. https://doi.org/10.3390/molecules25092021
Celebi D, Cinisli KT, Celebi O (2021) NanoBio challenge: Investigation of antimicrobial effect by combining ZnO nanoparticles with plant extract Eleagnus angustifolia. Mater Today Proc 45:3814–3818. https://doi.org/10.1016/j.matpr.2021.02.484
Chen Q, Chen J, Du H, Li Q, Chen J, Zhang G, Wang J (2014) Structural characterization and antioxidant activities of polysaccharides extracted from the pulp of Elaeagnus angustifolia L. Int J Mol Sci 15(7):11446–11455. https://doi.org/10.3390/ijms150711446
Comlekcioglu N (2019) Bioactive compounds and antioxidant activity in leaves of endemic and native Isatis spp in Turkey. Braz Arch Biol Technol 62:e19180330
Comlekcioglu N, Dağlı F, Çömlekcioğlu U, Aygan A (2022) Cornus mas ve Rosa canina Meyvelerinin Antioksidan Kapasitesi ve Bazı Fitokimyasal Özellikleri. Turk J Agric Food Sci Technol 10(9):1724–1731. https://doi.org/10.24925/turjaf.v10i9.1724-1731.5434
Dehghan MH, Soltani J, Kalantar E, Farnad M, Kamalinejad M, Khodaii Z, Natanzi MM (2016) Characterization of an antimicrobial extract from Elaeagnus angustifolia. Int J Enteric Pathog 2(3):10–20157. https://doi.org/10.17795/ijep20157
Dilek Tepe H, Doyuk F (2020) Determination of phytochemical content by chromatographic methods and antioxidant capacity in methanolic extract of jujube (Zizyphus jujuba Mill.) and oleaster (Elaeagnus a ngustifolia L.). Int J Fruit Sci 20(3):1876–1890. https://doi.org/10.1080/15538362.2020.1834900
Doğan M, Mohammed FS, Uysal İ, Mencik K, Kına E, Pehlivan M, Sevindik M (2023) Total antioxidant status, antimicrobial and antiproliferative potentials of Viola odorata (Fragrant Violet). J Fac Pharm Ankara Univ 47(3):784–791. https://doi.org/10.33483/jfpau.1161440
El-Chaghaby GA, Mohammed FS, Rashad S, Uysal I, Koçer O, Lekesiz Ö, Doğan M, Şabik AE, Sevindik M (2024) Genus Hypericum: General properties, chemical contents and biological activities. Egypt J Bot 64(1):1–26. https://doi.org/10.21608/ejbo.2023.217116.2378
Elmi F, Dehghan G, Beigzadeh B (2017) Qualitative and quantitative changes of essential composition in the flowers of some populations of Elaeagnus angustifolia. Adv Herb Med 3(1):1–6
Eraslan EC, Altuntas D, Baba H, Bal C, Akgül H, Akata I, Sevindik M (2021) Some biological activities and element contents of ethanol extract of wild edible mushroom Morchella esculenta. Sigma J Eng Nat Sci 39(1):24–28
Fakı R, Canbay HS, Gürsoy O, Yılmaz Y (2022) Antioxidant activity, physico-chemical and fatty acid composition of oleaster (Elaeagnus angustifolia L.) varieties naturally grown in western mediterranean region of Turkey. Akad Gıda 20(4):329–335. https://doi.org/10.24323/akademik-gida.1224295
Farzaei MH, Bahramsoltani R, Abbasabadi Z, Rahimi R (2015) A comprehensive review on phytochemical and pharmacological aspects of Elaeagnus angustifolia L. J Pharm Pharmacol 67(11):1467–1480. https://doi.org/10.1111/jphp.12442
Gecer MK (2023) Diversity in important fruit traits of Elaeagnus angustifolia L. genotypes from Northeastern Turkey. Erwerbs-Obstbau 65(2):363–367. https://doi.org/10.1007/s10341-022-00809-0
Hällzon P, Ötkür Z, Svanberg I (2022) Ethnobotany and Utilization of the Oleaster, Elaeagnus angustifolia L.(fam. Elaeagnaceae), in Eastern Turkestan. Orient Suecana 71:38–61. https://doi.org/10.33063/diva-484664
Hamidpour R, Hamidpour S, Hamidpour M, Shahlari M, Sohraby M, Shahlari N, Hamidpour R (2017) Russian olive (Elaeagnus angustifolia L.): From a variety of traditional medicinal applications to its novel roles as active antioxidant, anti-inflammatory, anti-mutagenic and analgesic agent. J Tradit Complement Med 7(1):24–29. https://doi.org/10.1016/j.jtcme.2015.09.004
Hamidpour R, Hamidpour S, Doostmohamadi P (2019) Chemistry, pharmacology and medicinal property of Russian olive (Elaeagnus angustifolia L.). Cancer Sci Res 6:1–7
Hassanzadeh Z, Hassanpour H (2018) Evaluation of physicochemical characteristics and antioxidant properties of Elaeagnus angustifolia L. Sci Hortic 238:83–90. https://doi.org/10.1016/j.scienta.2018.04.041
Hosseinzadeh H, Ramezani M, Namjo N (2003) Muscle relaxant activity of Elaeagnus angustifolia L. fruit seeds in mice. J Ethnopharmacol 84(2–3):275–278. https://doi.org/10.1016/S0378-8741(02)00331-8
Incilay G (2014) Volatile composition, antimicrobial and antioxidant properties of different parts from Elaeagnus angustifolia L. J Essent Oil Bear Plants 17(6):1187–1202. https://doi.org/10.1080/0972060X.2014.929044
Jia-Wen DING, Yi-Tong CHEN, Xiao XIE, Geng-Ping ZHU, Xiang-Ming LIU, Qiang LIU (2015) Comparison of four different approaches for the extraction of Elaeagnus angustifolia flower volatiles. Plant Science Journal 33(1):116–125. https://doi.org/10.11913/PSJ.2095-0837.2015.10116
Kalkan M, Aygan A, Çömlekçioglu N, Çömlekçioğlu U (2023) Olea europaea Yapraklarının Bazı Biyoaktif Özelliklerinin Araştırılması, Antimikrobiyal ve Enzim İnhibisyon Etkinliğinin İncelenmesi. Turk J Agric Sci Technol 11(3):496–504. https://doi.org/10.24925/turjaf.v11i3.496-504.5828
Karcioglu L, Tanis H, Comlekcioglu N, Diraz E, Kirecci E, Aygan A (2011) Antimicrobial activity of Salvia trichoclada in southern Turkey. Int J Agric Biol 13(1):134–136
Karkar B, Şahin S (2022) Determination of phenolic compounds profiles and antioxidant properties of oleaster (Elaeagnus angustifolia L.) grown in Turkey. Eur Food Res Technol 248(1):219–241. https://doi.org/10.1007/s00217-021-03875-y
Khan SU, Khan AU, Shah AUHA, Shah SM, Hussain S, Ayaz M, Ayaz S (2016) Heavy metals content, phytochemical composition, antimicrobial and insecticidal evaluation of Elaeagnus angustifolia. Toxicol Ind Health 32(1):154–161. https://doi.org/10.1177/0748233713498459
Korkmaz AI, Akgul H, Sevindik M, Selamoglu Z (2018) Study on determination of bioactive potentials of certain lichens. Acta Aliment 47(1):80–87. https://doi.org/10.1556/066.2018.47.1.10
Korkmaz N, Dayangaç A, Sevindik M (2021) Antioxidant, antimicrobial and antiproliferative activities of Galium aparine. J Fac Pharm Ankara Univ 45(3):554–564. https://doi.org/10.33483/jfpau.977776
Krupodorova T, Barshteyn V, Sevindik M (2022) Antioxidant and antimicrobial potentials of mycelial extracts of Hohenbuehelia myxotricha grown in different liquid culture media. BioTechnologia 103(1):19. https://doi.org/10.5114/bta.2022.113912
Lev E, Amar Z (2002) Ethnopharmacological survey of traditional drugs sold in the Kingdom of Jordan. J Ethnopharmacol 82(2–3):131–145. https://doi.org/10.1016/S0378-8741(02)00182-4
Liu Z, Ding D, Cui H, Wang C, Liu J, Chen L, Geng G (2021) A study on the volatile compounds in Elaeagnus angustifolia L. Flowers during flowering season by gas chromatography-mass spectrometry coupled with advanced Chemometrics. J Food Quality 2021(1):7111120. https://doi.org/10.1155/2021/7111120
Maghsoodlou MT, Kazemipoor N, Jafarazad R, Rahneshan N (2015) Essential oil composition of Elaeagnus angustifolia and Elaeagnus orientalis from Sistan and Baluchestan, Iran. J Med Herbs 6(2):109–112
Mahboubi M (2018) Elaeagnus angustifolia and its therapeutic applications in osteoarthritis. Ind Crops Prod 121:36–45. https://doi.org/10.1016/j.indcrop.2018.04.051
Mohammed FS, Günal S, Pehlivan M, Doğan M, Sevindik M, Akgül H (2020) Phenolic content, antioxidant and antimicrobial potential of endemic Ferulago platycarpa. Gazi Univ J Sci 33(4):670–677. https://doi.org/10.35378/gujs.707555
Mohammed FS, Kına E, Sevindik M, Doğan M, Pehlivan M (2021a) Antioxidant and antimicrobial activities of ethanol extract of Helianthemum salicifolium (Cistaceae). Indian J Nat Prod Resour 12(3):459–462. https://doi.org/10.56042/ijnpr.v12i3.46635
Mohammed FS, Pehlivan M, Sevindik E, Akgul H, Sevindik M, Bozgeyik I, Yumrutas O (2021b) Pharmacological properties of edible Asparagus acutifolius and Asparagus officinalis collected from North Iraq and Turkey (Hatay). Acta Aliment 50(1):136–143. https://doi.org/10.1556/066.2020.00204
Mohammed FS, Sevindik M, Uysal I (2023) Total phenolic, flavonoid, protein contents and biological activities of wild mustard. Acta Aliment 52(3):449–457. https://doi.org/10.1556/066.2023.00082
Mohammed FS, Sevindik M, Uysal İ, Çesko C, Koraqi H (2024) Chemical composition, biological activities, uses, nutritional and mineral contents of cumin (Cuminum cyminum). Meas Food. https://doi.org/10.1016/j.meafoo.2024.100157
Monjazeb Marvdashti L, Mohammadbeigi M, Arab S, Ebrahimi A, Rezaei A, Abdolshahi A (2024) Elaeagnus angustifolia L. Whole Fruit Ethanolic Extract: Phytochemical Composition and Antimicrobial Effects. J Chem Health Risk 1(1):117. https://doi.org/10.22034/jchr.2022.1899059.1130
Motevalian M, Shiri M, Shiri S, Shiri Z, Shiri H (2017) Anti-inflammatory activity of Elaeagnus angustifolia fruit extract on rat paw edema. J Basic Clin Physiol Pharmacol 28(4):377–381. https://doi.org/10.1515/jbcpp-2015-0154
Naseri Z, Piri K, Naseri M, Nuri S (2023) Anticancer, antioxidant and antibacterial activities of extracts from Scrophularia striata and Elaeagnus angustifolia, growing in Ilam and Kurdistan provinces in Iran. Plant Sci Today 10(1):152–165. https://doi.org/10.14719/pst.1941
Okmen G, Turkcan O (2014) A study on antimicrobial, antioxidant and antimutagenic activities of Elaeagnus angustifolia L. leaves. African J Tradit Complementary Altern Med 11(1):116–120. https://doi.org/10.4314/ajtcam.v11i1.17
Özer Z, Kiliç T, Selvi S, Pasa C (2018) Effect of different drying methods and development stages on the essential oil chemical composition of aerial parts of Origanum vulgare L. subsp. hirtum (link) Letsw. J Essent Oil Bearing Plants 21(5):1403–1409. https://doi.org/10.1080/0972060X.2018.1439774
Panasenko OI, Mozul VI, Denysenko OM, Aksonova II, Oberemko TV (2021) Chromato-mass-spectroscopic research of chemical composition of Elaeagnus angustifolia L. Curr Issues Pharm Med Sci Pract. https://doi.org/10.14739/2409-2932.2021.2.233708 (İnstituonal Repository of Zaporizhzhia State Medical Unıversity)
Pirbodaghi L, Alirezalu A, Ghasemi G (2023) Evaluation of phytochemical and morphological diversity the fruit of some Elaeagnus angustifolia L. ′Anabi′ genotypes in Urmia, Iran. Iran J Rangelands For Plant Breed Genet Res 31(1):116–131. https://doi.org/10.22092/IJRFPBGR.2023.362491.1439
Ramezani M, Hosseinzadeh H, Daneshmand N (2001) Antinociceptive effect of Elaeagnus angustifolia fruit seeds in mice. Fitoterapia 72(3):255–262. https://doi.org/10.1016/S0367-326X(00)00290-2
Saboonchian F, Jamei R, Sarghein SH (2014) Phenolic and flavonoid content of Elaeagnus angustifolia L.(leaf and flower). Avicenna J Phytomed 4(4):231
Sabouri S, Rad AH, Peighambardoust SH, Fathipour RB, Feshangchi J, Ansari F, Pourjafar H (2021) The oleaster (Elaeagnus angustifolia): A comprehensive review on its composition, ethnobotanical and prebiotic values. Curr Pharm Biotechnol 22(3):367–379. https://doi.org/10.2174/1389201020666191107112243
Sadat H, Alami K, Mousavi SY (2020) Effect of Afghan Senjed (Elaeagnus angustifolia L.) leaves aqueous alcoholic extract on blood glucose level of diabetic rats. Pharmacogn J. https://doi.org/10.5530/pj.2020.12.170
Sardarodiyan M, Mehraban SAM, Arianfar A (2016) The optimization and comparison of different extraction approaches (ultrasound and maceration) on chemical composition of Elaeagnus angustifolia L. extract. Ecophytochem J Med Plants 4(3):79–94
Say A, Sümbül A, Dirim E, Yaman M, Yildiz E (2024) Unravelling the genetic diversity of oleaster (Elaeagnus angustifolia L.) with multivariate analysis. Appl Fruit Sci 66(2):719–730. https://doi.org/10.1007/s10341-024-01043-6
Sevindik M, Akgul H, Akata I, Alli H, Selamoglu Z (2017) Fomitopsis pinicola in healthful dietary approach and their therapeutic potentials. Acta Aliment 46(4):464–469. https://doi.org/10.1556/066.2017.46.4.9
Sevindik M, Akgul H, Selamoglu Z, Braidy N (2021) Antioxidant, antimicrobial and neuroprotective effects of Octaviania asterosperma in vitro. Mycology 12(2):128–138. https://doi.org/10.1080/21501203.2020.1816584
Sevindik M, Gürgen A, Khassanov VT, Bal C (2024) Biological activities of ethanol extracts of Hericium erinaceus obtained as a result of optimization analysis. Foods 13(10):1560. https://doi.org/10.3390/foods13101560
Si CL, Qin PP, Lu YY, Wu L, Wang HH, Hui LF, Ni YH (2011) GC-MS analysis of chemical composition and free radical scavenging activity of Elaeagnus angustifolia bark. Adv Mater Res 183:854–858. https://doi.org/10.4028/www.scientific.net/AMR.183-185.854
Simsek M, Sufer Ö (2021) Physical, bioactive and textural properties of oleaster (Elaeagnus angustifolia L.) fruit from different locations in Turkey. Turk J Agric Food Sci Technol 9(4):723–727. https://doi.org/10.24925/turjaf.v9i4.723-727.4025
Syed AL, Shah GM, Ashfaq S, Abrar H, Baseerat N, Khan N, Ullah K (2023) GC-MS analysis, antimicrobial, antioxidant, phytochemical, and phytotoxic activities of Elaeagnus angustifolia L. using different extracts. Phytopharm Res J 2(3):1–12
Tehranizadeh ZA, Baratian A, Hosseinzadeh H (2016) Russian olive (Elaeagnus angustifolia) as a herbal healer. Bioimpacts Bi 6(3):155. https://doi.org/10.15171/bi.2016.22
Torbati M, Asnaashari S, Afshar FH (2016) Essential oil from flowers and leaves of Elaeagnus angustifolia (Elaeagnaceae): Composition, radical scavenging and general toxicity activities. Adv Pharm Bull 6(2):163. https://doi.org/10.15171/apb.2016.023
Uysal I (2023) Total phenolic and flavonoid contents and antioxidant, antimicrobial and antiproliferative activities of Polycarpon tetraphyllum. Kuwait J Sci 50(3):322–325. https://doi.org/10.1016/j.kjs.2023.02.022
Ya W, Shang-Zhen Z, Chun-Meng Z, Tao G, Jian-Ping M, Ping Z, Qiu-xiu R (2014) Research article antioxidant and Antitumor effect of different fractions of ethyl acetate part from Elaeagnus angustifolia L. Adv J Food Sci Technol 6(5):707–710
Zare A, Khorshidi J, Vafaee Y (2023) Natural biochemical and morphological diversity of oleaster (Elaeagnus angustifolia L.) genotypes from the west of Iran: applicable for conservation, domestication, and breeding. Genet Resour Crop Evol 70(8):2575–2592. https://doi.org/10.1007/s10722-023-01588-7
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M. Sevindik, T. Krupodorova, E. Sevindik, O. Koçer, I. Uysal and O. Ünal declare that they have no competing interests.
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Sevindik, M., Krupodorova, T., Sevindik, E. et al. Elaeagnus angustifolia L.: A Comprehensive Review of Its Biological Activities, Phenolic and Chemical Constituents, and Applications. Applied Fruit Science 67, 70 (2025). https://doi.org/10.1007/s10341-025-01294-x
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DOI: https://doi.org/10.1007/s10341-025-01294-x