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A comparison of fitting algorithms for diffusion-weighted MRI data analysis using an intravoxel incoherent motion model

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Abstract

Object

The objective of this study is to propose a modified VARiable PROjection (VARPRO) algorithm specifically tailored for fitting the intravoxel incoherent motion (IVIM) model to diffusion-weighted magnetic resonance imaging (DW-MRI) data from locally advanced rectal cancer (LARC).

Materials and methods

The proposed algorithm is compared with classical non-linear least squares (NLLS) analysis using the Levenberg-Marquardt (LM) algorithm and with two recently proposed algorithms for ‘segmented’ analysis. These latter two comprise two consecutive steps: first, a subset of parameters is estimated using a portion of data; second, the remaining parameters are estimated using the whole data and the previous estimates. The comparison between the algorithms was based on the \(R^2\) goodness-of-fit measure: performance analysis was carried out on real data obtained by DW-MRI on 40 LARC patients.

Results

The performance of the proposed algorithm was higher than that of LM in 64 % of cases; ‘segmented’ methods were poorer than our algorithm in 100 % of cases.

Conclusion

The proposed modified VARPRO algorithm can lead to better fit of the IVIM model to LARC DW-MRI data compared to other techniques.

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Authors and Affiliations

  1. Radiology Unit, Department of Diagnostic Imaging Radiant and Metabolic Therapy, Istituto Nazionale Tumori Fondazione Giovanni Pascale RCCS, Via Mariano Semmola, 80131, Naples, Italy

    Roberta Fusco & Antonella Petrillo

  2. Department of Electrical Engineering and Information Technologies, University ‘Federico II’ of Naples, Via Claudio, 21, Naples, Italy

    Mario Sansone

Authors
  1. Roberta Fusco
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  2. Mario Sansone
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  3. Antonella Petrillo
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Corresponding author

Correspondence to Mario Sansone.

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Conflict of interest

All authors declare that they have no conflict of interest to disclose.

Ethical approval

All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Declaration of Helsinki and its later amendments or comparable ethical standards.

Informed consent

Informed consent was obtained from all individual participants in the study.

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Fusco, R., Sansone, M. & Petrillo, A. A comparison of fitting algorithms for diffusion-weighted MRI data analysis using an intravoxel incoherent motion model. Magn Reson Mater Phy 30, 113–120 (2017). https://doi.org/10.1007/s10334-016-0591-y

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  • DOI: https://doi.org/10.1007/s10334-016-0591-y

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