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Allogreffe de cellules souches hématopoïétiques avec conditionnement à intensité réduite: situation en 2007 et perspectives

Reduced intensity allogeneic stem cell transplantation: current status (2007) and perspectives

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Oncologie

Résumé

L’allogreffe de cellules souches hématopoïétiques (allo-CSH) est une thérapeutique curative dans les hémopathies malignes. Cependant, du fait d’une toxicité rédhibitoire, l’utilisation de l’allo-CSH, notamment chez des patients âgés, ou chez des patients avec des comorbidités, reste limitée. La démonstration du rôle primordial de l’effet immunologique dans le contrôle de la maladie tumorale en post-allogreffe, a permis d’ouvrir la voie à l’utilisation des conditionnements à intensité réduite, qui privilégient la composante immunosuppressive à la composante chimiothérapique du conditionnement. L’objectif de cette revue est de faire le point sur cette stratégie thérapeutique en mettant l’accent sur les acquis cliniques actuels, les limitations et les perspectives futures.

Abstract

Allogeneic hematopoietic stem cell transplantation is a curative treatment for different hematological malignancies. However, because of a high rate of transplant-related mortality, the use of allo-CSH is limited in elderly patients or in patients with comorbidities. The demonstration of the major role of the immune system in disease control after allogeneic transplantation paved the way for the development of reduced intensity conditionings that favour the immunosuppressive component of the conditioning rather than the cytoreductive one. The aim of this review is to synthesize the available research evidence in this field, focusing on current clinical achievements, limitations and future perspectives.

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  1. Inserm UMR U601, service d’hématologie clinique, hôpital Hôtel-Dieu, CHU de Nantes, Université de Nantes, place Alexis-Ricordeau, F-44093, Nantes cedex 01, France

    M. Mohty

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Mohty, M. Allogreffe de cellules souches hématopoïétiques avec conditionnement à intensité réduite: situation en 2007 et perspectives. Oncologie 9, 842–847 (2007). https://doi.org/10.1007/s10269-007-0761-7

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  • DOI: https://doi.org/10.1007/s10269-007-0761-7

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