Résumé
La principale caractéristique de la tomothérapie hélicoïdale est de réaliser des traitements en radiothérapie conformation nelle avec modulation d’intensité sur un mode hélicoïdal gráce au déplacement de la table pendant la rotation de l’accélérateur selon le principe du scanner utilisé en radiodiagnostic. Le traitement est effectué avec des photons de 6 MV et la dégradation de cette énergie à 3 MV permet d’acquérir une imagerie pour la dosimétrie et de vérifier le positionnement quotidien du patient à chaque séance (technique de la radiothérapie guidée par l’image). Les premières études dosimétriques comparatives laissent entrevoir une certaine supériorité de la tomothérapie hélicoïdale sur les accélérateurs linéaires classiques. II est cependant nécessaire d’attendre les résultats des études cliniques en cours pour juger du bénéfice pour les patients en termes de tolérance et de contrôle local.
Abstract
The most important characteristic of the TomoTherapy® Hi-Art System™ is its combination of conformal intensity modulated radiation therapy with a helical radiation delivery pattern generated by the simultaneous movement of the treatment table and rotation of the accelerator, as in helical scanners used in medical imaging. Treatment makes use of 6 MV radiation, with the capacity to lower the level to 3 MV to determine patient positioning before each treatment session (image guided radiation therapy). Comparative dosimetric studies favoured helical tomotherapy over conventional linac systems, but the results of ongoing clinical studies are needed to evaluate the therapeutic gain for patients in terms of toxicity and local control.
Références
Bauman G, Yartsev S, Rodrigues G et al. (2007) A prospective evaluation of helical tomotherapy. Int J Radiat Oncol Biol Phys (in press)
Bauman G, Yartserv S, Coad T, et al. (2005) Helical tomotherapy for craniospinal radiation. Br J Radiol 78: 548–552
Fiorino C, Dell’Oca I, Pierelli A, et al. (2006) Significant improvement in normal tissue sparing and target coverage for head and neck cancer by means of helical tomotherapy. Radiother Oncol 78: 276–282
Followill D, Geis P, Boyer A (1997) Estimates of whole-body dose equivalent produced by beam intensity modulated conformal therapy. Int J Radiat Oncol Biol Phys 38: 667–672. Erratum appears in Int J Radiat Oncol Biol Phys 39: 783
Grigorov G, Kron T, Wong E, et al. (2003) Optimization of helical thomotherapy treatment plans for prostate cancer. Phys Med Biol 48: 1933–1943
Hall EJ, Wuu C (2003) Radiation-induced second cancers: the impact of 3D-CRT and IMRT. Int J Radiat Oncol Biol Phys 56: 83–88
Hodge W, Tome WA, Jaradat HA, et al. (2006) Feasibility report of image guided stereotactic body radiotherapy (IG-SBRT) with tomotherapy for early stage medically inoperable lung cancer using extreme hypofractionation. Acta Oncol 45: 890–896
Hui SK, Kapatoes J, Fowler J, et al. (2005) Feasibility study of helical tomotherapy for total body or total marrow irradiation. Med Phys 32: 3214–3224
Kantor G, Mahe MA, Giraud P, et al. (2006) Questions d’actualités: schéma général d’élaboration des protocoles de tomothérapie hélicoïdale pour chaque localisation. Cancer Radiother 10: 488–491
Mackie TR, Balog J, Ruchala K, et al. (1999) Thomotherapy. Semin Radiat Oncol 9: 108–117
Mahan SL, Ramsey CR, Scapertoth DD, et al. (2005) Evaluation of image-guided helical tomotherapy for the retreatment spinal metastasis. Int J Radiat Oncol Biol Phys 63: 1576–1583
Mutic A, Low D. (1998) Whole-body dose from tomotherapy delivery. Int J Radiat Oncol Biol Phys 42: 229–232
Penagaricano JA, Papanikolaou N, Yan Y, et al. (2005) Feasibility of cranio-spinal axis radiation with the Hi-Art tomotherapy system. Radiother Oncol 76: 72–78
Rodrigues G, Yartsev S, Chen J, et al. (2006) A comparison of prostate IMRT and helical tomotherapy class solutions. Radiother Oncol (in press)
Sheng K, Molloy JA, Read PW. (2006) Intensity-modulated radiation therapy (IMRT) dosimetry of the head-and-neck: a comparison of treatment plans using linear accelerator-based IMRT and helical tomotherapy. Int J Radiat Oncol Biol Phys 65: 917–923
Tomsej M (2006) Le système de tomothérapie hélicoïdale pour la radiothérapie modulée en intensité et guidée par l’image: développements récents et applications cliniques. Cancer Radiother 10: 288–295
Van Vulpen M, Field D, Raaijmakers CP, et al. (2005) Comparing step-and-shoot IMRT with dynamic helical tomotherapy IMRT plans for head-and-neck cancer. Int J Radiat Oncol Biol Phys 62: 1535–1539
Verellen D, Vanhavere F (1999) Risk assessment of radiation-induced malignancies based on whole-body equivalent dose estimates for IMRT treatment in the head and neck region. Radiother Oncol 53: 199–203
Wong JYC, Liu A, Schultheiss T, et al. (2006) Targeted total marrow irradiation using three-dimensional image-guided tomographic intensity-modulated radiation therapy: an alternative to standard total body irradiation. Biol Blood Marrow Transplant 12: 306–315
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Mahé, M.A., Lisbona, A., Mazal, A. et al. La tomothérapie hélicoïdale: un appareil dédié pour la RCMI. Oncologie 9, 447–450 (2007). https://doi.org/10.1007/s10269-007-0646-9
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DOI: https://doi.org/10.1007/s10269-007-0646-9
Mots clés
- Tomothérapie hélicoïdale
- Radiothérapie conformationnelle avec modulation d’intensité
- Radiothérapie guidée par l’image