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The role of FoxM1 in immune cells

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Abstract

Forkhead box M1 (FoxM1), a proliferation specific transcriptional modulator, plays a principal role in many physiological and pathological processes. FoxM1-mediated oncogenic processes have been well addressed. However, functions of FoxM1 in immune cells are less summarized. The literatures about the expression of FoxM1 and its regulation on immune cells were searched on PubMed and Google Scholar. In this review, we provide an overview on the roles of FoxM1 in regulating functions of immune cells, including T cells, B cells, monocytes, macrophages, and dendritic cells, and discuss their contributions to diseases.

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This work was supported by a grant from the National Natural Science Foundation of China (No. 82072927).

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Authors and Affiliations

  1. Biotherapy Center, Affiliated Qingdao Central Hospital of Qingdao University, Qingdao, China

    Jinju Zheng, Xiaofang Wei & Peng Zhao

  2. The Affiliated Cardiovascular Hospital of Qingdao University, Qingdao, China

    Xiaocui Bu

  3. Department of Oncology, Affiliated Qingdao Central Hospital of Qingdao University, Qingdao, China

    Xuezhen Ma

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JZ and PZ drafted the main body of this manuscript and drew the figures. XB, XW and XM modified the manuscript. PZ and XM took primary responsibility for this paper as the corresponding author. All authors contributed to the article and approved the submitted version.

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Correspondence to Xuezhen Ma or Peng Zhao.

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Zheng, J., Bu, X., Wei, X. et al. The role of FoxM1 in immune cells. Clin Exp Med 23, 1973–1979 (2023). https://doi.org/10.1007/s10238-023-01037-w

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