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Membranoproliferative glomerulonephritis following allogeneic hematopoietic stem cell transplantation

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Abstract

Nephrotic syndrome after allogeneic hematopoietic stem cell transplantation has been increasingly described as a manifestation of chronic graft-versus-host disease (GVHD); however, GVHD-associated membranoproliferative glomerulonephritis is extremely rare. A 44-year-old man developed nephrotic syndrome 24 months after HSCT for acute lymphoblastic leukemia. The renal biopsy showed type I membranoproliferative glomerulonephritis. Salivary gland biopsy demonstrated mild lymphocytic infiltration, indicating chronic GVHD. Improvement of the proteinuria and recovery of renal function were achieved within 11 months of treatment with oral prednisolone and azathioprine.

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Authors and Affiliations

  1. Division of Nephrology, Department of Internal Medicine, Yeouido St. Mary’s Hospital, The Catholic University of Korea, 62 Yeouido-dong, Yeongdeungpo-gu, Seoul, 150-713, Republic of Korea

    Ju Youn Kim, Min Young Lee, Biro Kim, Yoon Sik Chang & Sungjin Chung

  2. Division of Nephrology, Department of Internal Medicine, Seoul St. Mary’s Hospital, The Catholic University of Korea, 505 Banpo-dong, Seocho-gu, Seoul, 137-701, Republic of Korea

    Cheol Whee Park

Authors
  1. Ju Youn Kim
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  2. Min Young Lee
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  3. Biro Kim
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  4. Cheol Whee Park
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  5. Yoon Sik Chang
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  6. Sungjin Chung
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Correspondence to Sungjin Chung.

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Kim, J.Y., Lee, M.Y., Kim, B. et al. Membranoproliferative glomerulonephritis following allogeneic hematopoietic stem cell transplantation. Clin Exp Nephrol 14, 630–632 (2010). https://doi.org/10.1007/s10157-010-0337-5

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  • DOI: https://doi.org/10.1007/s10157-010-0337-5

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