Abstract
Background
Pelvic exenteration represents the best treatment option for cure of locally advanced or recurrent rectal cancer. This systematic review sought to evaluate current literature regarding short and long term treatment outcomes and long term survival following pelvic exenteration.
Methods
A systematic search of the MEDLINE, PubMed and Ovid databases was conducted to identify suitable articles published between 2001 and 2016. The article search was performed in line with Cochrane methodology and reported according to the Preferred Reporting Items for Systematic reviews and Meta-analyses statement.
Results
Sixteen studies were included in the final analysis, incorporating 1016 patients. Sixty-three percent of patients were male and median patient age was 59 years. Median operating time was 7.2 h with median blood loss of 1.9 l. Median postoperative stay was 17 days with a median 30-day mortality of 0. Complication rates were 31.6–86% with a return to theatre rate of 14.6%. Median R0 resection rate was 74% and was higher for primary cancer (82.6% versus 58% for recurrent cancer). Mean overall survival was 31 months and median 5-year survival was 32%. Recurrently identified indicators of adverse outcome included R1/2 resection, preoperative pelvic pain and previous abdominoperineal resection of the rectum.
Conclusions
Pelvic exenteration remains a major operation associated with significant morbidity and mortality. Despite advances in preoperative assessment and staging, R1 resection rates remain high. There is also a high degree of variability of reporting outcomes and standardisation of this process would aid comparison of results between centres and drive forward research in this area.
Similar content being viewed by others
References
Sigurdsson HK, Korner H, Dahl O et al (2007) Clinical characteristics and outcomes in patients with advanced rectal cancer: a national prospective cohort study. Dis Colon Rectum 50(3):285–291
Kokelaar RF, Evans MD, Davies M, et al (2016) Locally advanced rectal cancer: management challenges. Oncotargets Ther 9:6265–6272
Moriya Y (2006) Treatment strategy for locally recurrent rectal cancer. Jpn J Clin Oncol 36(3):127–131
Brunschwig A (1948) Complete excision of pelvic viscera for advanced carcinoma; a one-stage abdominoperineal operation with end colostomy and bilateral ureteral implantation into the colon above the colostomy. Cancer 1(2):177–183
Williams LF, Huddleston CB, Sawyers JL et al (1988) Is total pelvic exenteration reasonable primary treatment for rectal carcinoma? Ann Surg 207(6):670–678
Yang TX, Morris DL, Chua TC et al (2013) Pelvic exenteration for rectal cancer: a systematic review. Dis Colon Rectum 56(4):519–531
Beets-Tan RGH, Beets GL, Vliegen RFA et al (2001) Accuracy of magnetic resonance imaging in prediction of tumour-free resection margin in rectal cancer surgery. Lancet 357:497–504
Higgins J, Green S (2008) Cochrane handbook for systematic reviews of interventions. Wiley-Blackwell, Oxford
Abu-Zidan FM, Abbas AK, Hefny AF et al (2012) Clinical “case series”: a concept analysis. Afr Health Sci 12(4):557–562
Moher D, Liberati A, Tetzlaff J et al (2009) Preferred reporting items for systematic reviews and meta-analyses: the PRISMA Statement. Open Med 3(3):e123–e130
Kim SY, Park JE, Lee YJ et al (2013) Testing a tool for assessing the risk of bias for nonrandomised studies showed moderate reliability and promising validity. J Clin Epidemiol 66(4):408–414
Hozo SP, Djulbegovic B, Hozo I et al (2005) Estimating the mean and variance from the median, range, and the size of a sample. BMC Med Res Methodol 5(1):13
Yamada K, Ishizawa T, Niwa K et al (2002) Pelvic exenteration and sacral resection for locally advanced primary and recurrent rectal cancer. Dis Colon Rectum 45(8):1078–1084
Wiig JN, Poulsen JP, Larsen S et al (2002) Total pelvic exenteration with preoperative irradiation for advanced primary and recurrent rectal cancer. Eur J Surg 168(1):42–48
Jimenez RE, Shoup M, Cohen AM et al (2003) Contemporary outcomes of total pelvic exenteration in the treatment of colorectal cancer. Dis Colon Rectum 46(12):1619–1625
Moriya Y, Akasu T, Fujita S, Yamamoto S (2004) Dis Colon Rectum 47(12):2047–2054
Vermaas M, Ferenschild FT, Verhoef C et al (2007) Total pelvic exenteration for primary locally advanced and locally recurrent rectal cancer. Eur J Surg Oncol 33(4):452–458
Gannon CJ, Zager JS, Chang GJ et al (2007) Pelvic exenteration affords safe and durable treatment for locally advanced rectal carcinoma. Ann Surg Oncol 14(6):1870–1877
Ferenschild FTJ, Vermaas M, Verhoef C et al (2009) Total pelvic exenteration for primary and recurrent malignancies. World J Surg 33(7):1502–1508
Hsu TW, Chiang FF, Chen MC, Wang HM (2011) Pelvic exenteration for men with locally advanced rectal cancer: a morbidity analysis of complicated cases. Asian J Surg 34(3):115–120
Kuhrt MP, Chokshi RJ, Arrese D, Martin EW Jr (2012) Retrospective review of pelvic malignancies undergoing total pelvic exenteration. World J Surg Oncol 10(1):110
Nielsen MB, Rasmussen PC, Lingegaard JC, Laurberg S (2012) A 10-year experience of total pelvic exenteration for primary advanced and locally recurrent rectal cancer based on a prospective database. Colorectal Dis 14(9):1076–1083
López-Basave HN, Morales-Vásquez F, Herrera-Gómez Á et al (2012) Pelvic exenteration for colorectal cancer: oncologic outcome in 59 patients at a single institution. Cancer Manag Res 4(1):351–356
Xin KY, Ng DWJ, Tan GHC, Teo MCC (2014) Role of pelvic exenteration in the management of locally advanced primary and recurrent rectal cancer. J Gastrointest Cancer 45:291–297
Carballo L, Enriquez-Navascues JM, Saralegui Y et al (2015) Total pelvic exenteration for the treatment of advanced primary or recurrent pelvic neoplasia. Cir Esp 93(3):174–180
Yang HY, Park SC, Hyun JH et al (2015) Outcomes of pelvic exenteration for recurrent or primary locally advanced colorectal cancer. Ann Surg Treat Res 89(3):131–137
Radwan RW, Jones HG, Rawat N et al (2015) Determinants of survival following pelvic exenteration for primary rectal cancer. Br J Surg 102(10):1278–1284
Milne T, Solomon MJ, Lee P et al (2014) Sacral resection with pelvic exenteration for advanced primary and recurrent pelvic cancer: a single-institution experience of 100 sacrectomies. Dis Colon Rectum 57(10):1153–1161
Bhangu A, Ali M, Brown G et al (2014) Indications and outcome of pelvic exenteration for locally advanced primary and recurrent rectal cancer. Ann Surg 259(2):315–322
Swinney C, Li A, Bhatti I, Veeravagu A (2016) Optimization of tumor resection with intra-operative magnetic resonance imaging. J Clin Neurosci. 34:11–14
Clarke M, Williamson P (2016) Core outcome sets and systematic reviews. Syst Rev 16:216
McNair AGK, Whistance RN, Forsythe RO et al (2016) Core outcomes for colorectal cancer surgery: a consensus study. PLoS Med. 13(8):e1002071
Funding
No grant support or financial relationship, no funding received.
Author information
Authors and Affiliations
Contributions
EP—data acquisition/analysis, drafting the work, final approval and agreement to be accountable. GD—data acquisition/analysis, final approval and agreement to be accountable. SS—data analysis, critical revision of work, final approval and agreement to be accountable.
Corresponding author
Ethics declarations
Conflict of interest
The authors declare they have no conflict of interest.
Ethical approval
This study does not contain any studies with human participants or animals performed by any of the authors.
Informed consent
For this type of study formal consent is not required.
Rights and permissions
About this article
Cite this article
Platt, E., Dovell, G. & Smolarek, S. Systematic review of outcomes following pelvic exenteration for the treatment of primary and recurrent locally advanced rectal cancer. Tech Coloproctol 22, 835–845 (2018). https://doi.org/10.1007/s10151-018-1883-1
Received:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s10151-018-1883-1