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Pure and non-pure meningioangiomatosis of 36 Chinese patients: an analysis of clinical presentation, diagnosis, histopathology and prognosis

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Abstract

Meningioangiomatosis (MA) is a disease that is extremely rarely reported. Sporadic MA is occasionally combined with meningioma or other lesions (identified as non-pure MA). This retrospective study investigated the difference between pure MA and non-pure MA by exploring clinical manifestations, histopathology characteristics, and outcomes of MA after surgery. We reviewed the medical records of 36 histopathologically confirmed MA patients (18 pure MA and 18 non-pure MA) who received surgery at our institution between 2012 and 2021. We compared differences in demographic, clinical, imaging, pathological features, and surgical outcomes between pure MA and non-pure MA through descriptive statistics. Compared to non-pure MA, pure MA presented with a more prominent male predilection (5:1 vs. 1.57:1, P = 0.264), a higher seizure incidence (83.3% vs 50.0%, P = 0.038), a more seizure type of GTCS (14/15 vs 5/9, P = 0.047), a less prominent enhancement on MRI (27.8% vs 88.9%, P < 0.001) and a preference of temporal and frontal lobe (100% vs 44.4%, P < 0.001). The differences in clinical characteristics between pure MA and non-pure MA demonstrate their disparate biological natures. Pure MA seems to be a non-neoplastic lesion, while non-pure MA is commonly combined with meningioma, which is a neoplastic lesion. A correct differential diagnosis can be achieved via a triad of the type of seizure, the location of lesion and the radiological presentation. MA is curable and the prognosis is excellent as most patients are free of seizure and recurrence after surgical treatment.

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Data availability

The data collected for the study will be made available upon request via email to the corresponding author. All data is available on request.

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Acknowledgements

The authors would like to thank all the patients who trusted them and the neuropathologist (Xing Liu and Gui-Lin Li) in the Department of Neuropathology at Beijing Neurosurgical Institute who helped them in this study.

Author information

Author notes

  1. Guo-Bin Zhang, Yu-Zhe Ying, and Hua-Wei Huang contributed equally to the work and are considered co-first authors.

Authors and Affiliations

  1. Department of Neurosurgery, China National Clinical Research Center for Neurological Diseases (NCRC-ND), Center of Brain Tumor, Beijing Key Laboratory of Brian Tumor, Fengtai District, Beijing Institute for Brain Disorders, Beijing Tiantan Hospital, Capital Medical University, South 4th Ring West Road 119, 100050, Beijing, People’s Republic of China

    Guo-Bin Zhang, Yu-Zhe Ying, Hao-Yi Li, Xiao-Kang Zhang, Yong-Gang Wang, Yong Cui, Zhong-Li Jiang & Song Lin

  2. Department of Critical Care Medicine, Beijing Tiantan Hospital, Capital Medical University, Beijing, 100050, People’s Republic of China

    Hua-Wei Huang

  3. Department of Neurosurgery, The Third Clinical Medical College, Fujian Medical University, Fuzhou, 350001, People’s Republic of China

    Wei-Jie Yu

  4. Department of Biomedical Informatics, Vanderbilt University Medical Center, Nashville, TN, 37232, USA

    You Chen

  5. Department of Electrical Engineering & Computer Science, Vanderbilt University, Nashville, TN, 37235, USA

    You Chen

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  1. Guo-Bin Zhang
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Contributions

Conception and design of the study: Guo-Bin Zhang, Yu-Zhe Ying, and Hua-Wei Huang. Acquisition or interpretation of data: Wei-Jie Yu, Hao-Yi Li, Xiao-Kang Zhang. Statistical analysis: Yong-Gang Wang and Yong Cui. Drafting the article: Guo-Bin Zhang. Revising the manuscript critically for important intellectual content: You Chen, Zhong-Li Jiang, and Song Lin. Final approval of the submitted version: all authors.

Corresponding authors

Correspondence to Zhong-Li Jiang or Song Lin.

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All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional or national research committee and with the 1964 Helsinki Declaration and its later amendments or comparable ethical standards. Informed consent was obtained from all individual participants included in the study.

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Zhang, GB., Ying, YZ., Huang, HW. et al. Pure and non-pure meningioangiomatosis of 36 Chinese patients: an analysis of clinical presentation, diagnosis, histopathology and prognosis. Neurosurg Rev 45, 3405–3415 (2022). https://doi.org/10.1007/s10143-022-01855-8

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