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Case-control study on association of peroxisome proliferator-activated receptor-δ and SNP-SNP interactions with essential hypertension in Chinese Han population

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Abstract

The aim of this study was to investigate the association of peroxisome proliferator-activated receptor-δ (PPAR-δ) and additional SNP-SNP interaction with essential hypertension (EH) in Chinese Han population. A total of 1248 subjects (625 males, 623 females), including 620 EH patients and 628 normotension subjects, were included in the study. The mean age was 51.2 ± 15.1 years old. Logistic regression model was used to examine the association between four SNP and EH; odds ratio (OR) and 95 % confident interval (95 %CI) were calculated. Generalized multifactor dimensionality reduction (GMDR) was employed to analyze SNP-SNP interaction. EH risk was significantly lower in carriers of C allele of the rs2016520 polymorphism than those with TT (TC + CC versus TT, adjusted OR (95 %CI) = 0.61 (0.49–0.78)). In addition, we also found a significant association between rs9794 and EH; EH risk was also significantly lower in carriers of G allele of the rs9794 polymorphism than those with CC (CG + GG versus CC, adjusted OR (95 %CI) = 0.65 (0.53–0.83)). We also found a potential SNP-SNP interaction between rs2016520 and rs9794; subjects with TC or CC of rs2016520 and CG or GG of rs9794 genotype have the lowest EH risk, compared to subjects with TT of rs2016520 and CC of rs9794 genotype; OR (95 %CI) was 0.32 (0.23–0.62) after covariate adjustment. Our results support an important association between rs2016520 and rs9794 minor allele of PPAR-δ and decreased risk of EH and additional interaction between rs2016520 and rs9794.

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Acknowledgments

The writing of this paper was supported by the First Hospital of Jilin University. We thank all partners and staff who helped us in the process of this study.

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Authors and Affiliations

  1. Changchun Medical College in Pediatrics, Changchun, 130031, China

    Yubo Li

  2. Department of Cardiovascular Division, The First Clinical Hospital of Jilin University, Changchun, 130031, China

    Guoqiang Sun

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  1. Yubo Li
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  2. Guoqiang Sun
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Correspondence to Guoqiang Sun.

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Li, Y., Sun, G. Case-control study on association of peroxisome proliferator-activated receptor-δ and SNP-SNP interactions with essential hypertension in Chinese Han population. Funct Integr Genomics 16, 95–100 (2016). https://doi.org/10.1007/s10142-015-0469-5

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  • DOI: https://doi.org/10.1007/s10142-015-0469-5

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