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Complication rates and safety of pulsed dye laser treatment for port-wine stain: a systematic review and meta-analysis

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Abstract

Pulsed dye laser (PDL) is the most commonly used method for port-wine stain (PWS); however, no studies have reported the safety of PDL. This review aimed to collect and summarize complications reported in relevant literature, assess complication rates in treating PWS with PDL, and explore the relevant influencing factors. A systematic review and meta-analysis were conducted to search for related studies in PubMed, Embase, and the Cochrane Library until August 2022. Two reviewers independently evaluated the risk of bias of included studies. Stata Software version 17.0 was used for the analysis. All complications reported in the literature are divided into acute phase complications and long-term complications. Overall pooled purpura, edema, crusting, blistering, hyperpigmentation, hypopigmentation, and scarring rates were 98.3%, 97.6%, 21.5%, 8.7%, 12.8%, 0.9%, and 0.2%, respectively. Although the acute adverse reactions were found to be common, the long-term permanent complications clearly have a lower frequency, and the occurrence of scarring is much lower than that initially thought. This indicates that effective protective measures after treatment are very important for preventing scar formation. Overall, PDL treatment for PWS shows a high level of safety and low chances of causing long-term complications.

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The data used in the manuscript are extracted from the published articles (primary studies). All such primary studies are cited in the manuscript with complete reference provided in the reference list. The data extracted are summarized in the tables, figures and supporting information included in the manuscript.

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  1. Department of Burn and Plastic Surgery, Shandong Provincial Hospital, Shandong University, No. 324, Jing Wu Road, Jinan, 250021, China

    Meng dong Shi, Kun Yang & Ran Huo

  2. Department of Burn and Plastic Surgery, The People’s Hospital Of Huaiyin Jinan, Jinan, China

    Shu bo Li

  3. Department of Burn and Plastic Surgery, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, China

    Qian Zhao, Ran Huo & Cong Fu

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Shi, M.d., Yang, K., Li, S.b. et al. Complication rates and safety of pulsed dye laser treatment for port-wine stain: a systematic review and meta-analysis. Lasers Med Sci 39, 16 (2024). https://doi.org/10.1007/s10103-023-03961-5

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