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Nonsurgical periodontal therapy with/without diode laser modulates metabolic control of type 2 diabetics with periodontitis: a randomized clinical trial

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Abstract

In order to evaluate whether nonsurgical periodontal treatment with/without diode laser (DL) decontamination improves clinical parameters, the levels of IL-1β, IL-6, IL-8, intercellular adhesion molecule (ICAM), and vascular cell adhesion molecule (VCAM) in gingival crevicular fluid and metabolic control (HbA1c) in chronic periodontitis (CP) patients with diabetes mellitus type 2 (DM2). Sixty patients with DM2 and CP were randomly assigned into two groups to receive scaling and root planing (SRP, n = 30) or SRP followed by diode laser application (SRP + DL, n = 30). Clinical periodontal and gingival crevicular fluid (GCF) parameters were assessed at baseline, 1, and 3 months after periodontal treatment. HbA1c levels were evaluated at baseline and 3 months post-therapy. Total amounts of cytokines and molecules were analyzed by ELISA. Nonsurgical periodontal treatment with/without DL appeared to improve clinical, biochemical parameters, and glycemic control in DM2 patients (BMI < 25 kg/m2) with CP. The SRP + DL group provided better reductions in probing depth (PD) and clinical attachment level (CAL) parameters compared to the SRP group (P < 0.05). Significant reductions were found in the total amounts of GCF levels of IL-1, IL-6, IL-8, ICAM, and VCAM after treatment (P < 0.05). HbA1c levels decreased significantly at 3 months after treatment (P < 0.05). SRP + DL reduced HbA1c levels more significantly compared to SRP alone (0.41 vs. 0.22 %, P < 0.05). SRP, especially in combination with DL, shows improvement of glycemic control for DM2 patients with CP.

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Authors and Affiliations

  1. Department of Periodontology, Faculty of Dentistry, Selcuk University, Konya, Turkey

    Emrah Koçak & Sema S. Hakkı

  2. Department of Periodontology, Faculty of Dentistry, Izmir Katip Celebi University, Izmir, Turkey

    Mehmet Sağlam

  3. Department of Biostatistics, Faculty of Medicine, Karabük University, Karabuk, Turkey

    Seyit Ali Kayış

  4. Research Center of Dental Faculty, Selcuk University, Konya, Turkey

    Niyazi Dündar & Sema S. Hakkı

  5. Department of Endocrinology and Metabolism Disease, School of Medicine, Selcuk University, Konya, Turkey

    Levent Kebapçılar

  6. Department of Periodontology, Academic Center for Dentistry Amsterdam (ACTA), University of Amsterdam and VU University Amsterdam, Amsterdam, The Netherlands

    Bruno G.Loos

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  1. Emrah Koçak
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  2. Mehmet Sağlam
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  3. Seyit Ali Kayış
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Correspondence to Mehmet Sağlam.

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The authors declare no potential conflicts of interest with respect to the authorship and/or publication of this article. This study was supported by the Research Project Coordination of Selcuk University (project no. 11202014) and The Scientific and Technological Research Council of Turkey (TUBITAK/SBAG-114S229). Author BGL is supported in part by a grant of the University of Amsterdam (focal point “Oral Infections and Inflammation”).

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Koçak, E., Sağlam, M., Kayış, S.A. et al. Nonsurgical periodontal therapy with/without diode laser modulates metabolic control of type 2 diabetics with periodontitis: a randomized clinical trial. Lasers Med Sci 31, 343–353 (2016). https://doi.org/10.1007/s10103-016-1868-0

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