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Characteristics of endovascular pneumococcal infections; a decade of nationwide surveillance study

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Abstract

In order to characterize pneumococcal endovascular infection in the post-vaccination era, a retrospective nationwide study based on the Israeli Adult IPD database was conducted. Between 2010 and 2019, 0.6% (23 cases) of IPD cases were of endovascular type, occurring mainly in males (72.3%) with underlying medical conditions (78.2%). Additional pneumococcal source (10 patients) and concomitant infections were not uncommon. Penicillin and ceftriaxone susceptibility rates were 65.2% and 91.3%, respectively; 60.9% of the isolates were not covered by the pneumococcal conjugate vaccine. 21.7% of patients died during hospitalization. In conclusion, pneumococcal endovascular infections still carry significant morbidity and mortality.

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Data availability

The datasets generated during and/or analyzed during the current study are available in the IAIPD repository.

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Acknowledgements

We greatly acknowledge Ronit Trefler for serotyping, and Efrat Steinberger and Etti Kreiff for their assistance in data collection and management.

The IAIPD study principal investigator was Gili Regev-Yochay and the IsraNIP Project principal investigator was Ron Dagan. Additional members of the IAIPD group who contributed: Marc Assous, Yonit Wiener-Well (Shaare Zedek Medical Center, Jerusalem, Israel); Haim Ben-Zvi, Hila Shaked, Jihad Bishara (Rabin Medical Center, Petah Tikva, Israel); Rita Bardenstein, Oren Zimchony (Kaplan Medical Center, Rehovot, Israel); Larissa Brik, Ariella Levkovich, Miriam Weinberger (Assaf Harofeh Medical Center, Tzrifin, Israel); Bibiana Chazan, Yoram Kennes (HaEmek Medical Center, Afula, Israel); Michal Chowers, Yosi Paitan (Meir Medical Center, Kfar Saba, Israel); Ronit Cohen-Poradosu, Talia Finn, Yael Paran, David Schwartz, Michal Katzir (Tel Aviv Medical Center, Tel Aviv, Israel); Alicia Embon, Yevgenia Tziba (Barzilai Medical Center, Ashkelon, Israel); Sarit Freimann, Valery Istomin (Hillell Yaffe Medical Center, Hadera, Israel); Yuval Geffen, Renato Finkelstein, Ilana Oren (Rambam Medical Center, Haifa, Israel); Danny Glikman, Shifra Sela (Western Galilee Hospital, Nahariya, Israel); Mirit Hershman, Israel Potasman, Itzhak Srugo (Bnai Zion Medical Center, Haifa); Gill Smollan, Galia Rahav (Sheba Medical Center, Ramat Gan, Israel); Camellia Khoury-Assi (French Hospital, Nazareth, Israel); Mandelbaum Sari, Regev Cohen (Laniado Hospital–Sanz Medical Center, Netanya, Israel); Yasmin Maor, Orna Schwartz, Michal Stein (Edith Wolfson Medical Center, Holon, Israel); Danny Miron, Hagai Rechnitzer (Ziv Medical Center, Safed, Israel); Nehama Peled, Nurit Porat, Klaris Reisenberg (Soroka University Medical Center, Beersheba, Israel); Pninit Shaked-Mishan, Gabriel Weber (Carmel Medical Center, Haifa); Yehudit Sheindler (Maayanei Hayeshua Hospital, Bnei Brak, Israel); Hiba Abu Zaid (Peoria Medical Center, Tiberias, Israel); Jacob Strahilevitz, Violetta Temper (Hadassah-Hebrew University, Jerusalem); Olga Sverdlob (Maccabi Healthcare Services, Rehovot).

Funding

The IAIPD is part of the IsraNIP project. This study was supported in part by Wyeth (Pfizer), manufacturer of Prevnar 7 and Prevnar 13 [grant no. 0887Z1-4603]. Wyeth (Pfizer) had no role in designing the study, collecting the data, analyzing the data, interpreting the data, writing the report, or in the decision to submit the paper for publication.

Author information

Author notes

  1. Ariel Kenig and Yonatan Oster contributed equally to this work.

Authors and Affiliations

  1. Department of Medicine, Hadassah Hebrew University Medical Center, Jerusalem, Israel

    Ariel Kenig

  2. Faculty of Medicine, Hebrew University of Jerusalem, Jerusalem, Israel

    Ariel Kenig, Yonatan Oster & Jacob Strahilevitz

  3. Department of Clinical Microbiology and Infectious Diseases, Hadassah Hebrew University Medical Center, Ein Kerem, 91120, Jerusalem, Israel

    Yonatan Oster & Jacob Strahilevitz

  4. Infectious Diseases Unit, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel

    Ronit Cohen-Poradosu

  5. Infectious Disease Unit, Soroka University Medical Center, Beer Sheva, Israel

    Klaris Reisenberg

  6. Infectious Disease Unit, Sheba Medical Center, Ramat Gan, Israel

    Anat Wieder-Finesod

  7. Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel

    Anat Wieder-Finesod & Gili Regev-Yochay

  8. Bnai Zion Medical Center, Haifa, Israel

    Mirit Hershman-Sarafov

  9. Infectious Disease Unit, Rambam Medical Center, Haifa, Israel

    Ilana Oren

  10. Infectious Disease Unit, Carmel Medical Center, Haifa, Israel

    Gabriel Weber

  11. Faculty of Medicine Technion, Israel Institute of Technology, Haifa, Israel

    Gabriel Weber

  12. Faculty of Health Science, Ben-Gurion University of the Negev, Beer Sheva, Israel

    Ron Dagan

  13. Infection Prevention & Control Unit, Sheba Medical Center, Ramat Gan, Israel

    Gili Regev-Yochay

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  1. Ariel Kenig
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Contributions

AK, YO, GRY, and JS developed the conceptual design of the study. AK and JS collected clinical data. AK, YO, and JS performed data analysis and wrote the manuscript. RCP, KR, AWF, MHS, IO, GW, RD, and GRY critically reviewed the manuscript.

Corresponding author

Correspondence to Jacob Strahilevitz.

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Ethics committee approval: Sheba 7415–09.

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The authors declare no competing interests.

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Kenig, A., Oster, Y., Cohen-Poradosu, R. et al. Characteristics of endovascular pneumococcal infections; a decade of nationwide surveillance study. Eur J Clin Microbiol Infect Dis 41, 1365–1370 (2022). https://doi.org/10.1007/s10096-022-04500-w

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