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Association between the rate of third generation cephalosporin-resistant Escherichia coli and Klebsiella pneumoniae and antibiotic consumption based on 143 Chinese tertiary hospitals data in 2014

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European Journal of Clinical Microbiology & Infectious Diseases Aims and scope Submit manuscript

Abstract

This study sought to discuss the correlation between the third-generation cephalosporins (3GC)-resistant Escherichia coli and Klebsiella pneumoniae and antibiotic consumption intensity from 143 Chinese tertiary hospitals in 2014. With a retrospective design, the correlation between antibiotic consumption and 3GC-resistant E. coli and K. pneumoniae were performed. 3GC-resistant E. coli was significantly correlated with the consumption of all antibiotics (r = 0.252, p < 0.01), β-Lactams antibiotics (r = 0.313, p < 0.01), β-Lactams excluding combinations with β-lactamase inhibitors (r = 0.365, p < 0.01), cephalosporin (r = 0.398, p < 0.01), cephalosporins excluding combinations with β-lactamase inhibitors (r = 0.374, p < 0.01), 3GC (r = 0.321, p < 0.01), and 3GC excluding combinations with β-lactamase inhibitors (r = 0.343, p < 0.01). 3GC-resistant K. pneumoniae was significantly correlated with the consumption of all antibiotics (r = 0.200, p < 0.05), β-Lactams antibiotics (r = 0.232, p < 0.01), cephalosporin (r = 0.215, p < 0.05), 3GC (r = 0.383, p < 0.01), 3GC excluding combinations with β-lactamase inhibitors (r = 0.245, p < 0.01), and β-lactam-β-lactamase inhibitor combinations (r = 0.218, p < 0.05). There was a significant relationship between the antibiotic consumption and the rates of 3GC-resistant E. coli and K. pneumoniae. Clinicians should grasp the indication of antibiotics use to reduce the production of drug-resistant bacteria.

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Funding

This study was sponsored by National Natural Science Foundation of China (81361138021, 81711530049), Key Research and Development Program of Zhejiang Province (2015C03032), and Zhejiang Province Medical Science and Technology Project (2017KY339).

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Authors and Affiliations

  1. Department of Pharmacy, the First Affiliated Hospital of Medicine School, Zhejiang University, Hangzhou, China

    Ping Yang, Saiping Jiang & Xiaoyang Lu

  2. State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, the First Affiliated Hospital of Medicine School, Zhejiang University, Hangzhou, China

    Yunbo Chen, Ping Shen & Yonghong Xiao

Authors
  1. Ping Yang
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  2. Yunbo Chen
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  3. Saiping Jiang
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  4. Ping Shen
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  5. Xiaoyang Lu
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  6. Yonghong Xiao
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Correspondence to Yonghong Xiao.

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Given that this study was performed without accessing patient information, approval of the ethics committee was not required.

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Yang, P., Chen, Y., Jiang, S. et al. Association between the rate of third generation cephalosporin-resistant Escherichia coli and Klebsiella pneumoniae and antibiotic consumption based on 143 Chinese tertiary hospitals data in 2014. Eur J Clin Microbiol Infect Dis 39, 1495–1502 (2020). https://doi.org/10.1007/s10096-020-03856-1

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  • DOI: https://doi.org/10.1007/s10096-020-03856-1

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