Abstract
Background
High repetitions of task practice is required for the recovery of the motor function during constraint-induced movement therapy (CIMT). This can be achieved into ways: when the task practice is measured in hours of practice or when the number of repetitions is counted. However, it has been argued that using hours of task practice as a measure of practice does not provide a clear instruction on the dose of practice.
Aim
The aim of this study is to determine the feasibility and effects of the CIMT protocol that uses the number of repetitions of task practice.
Materials/method
The study was a systematic review registered in PROSPERO (CRD42020142140). Five databases, PubMED, CENTRAL, PEDro, OTSeeker and Web of Science, were searched. Studies of any designs in adults with stroke were included if they used the number of repetitions of task practice as a measure of dose. The methodological quality of the included studies was assessed using Modified McMaster critical review form. The results were analysed using qualitative synthesis.
Results
Eight studies (n = 205) were included in the study. The number of task repetitions in the studies ranges between 45 and 1280 per day. The results showed that CIMT protocol using the number of repetitions of task practice was feasible and improved outcomes such as motor function, quality of life, functional mobility and spasticity.
Conclusion
The number of repetitions of task practice as a measure of CIMT dose can be used in place of the existing protocol that uses the number of hours of task practice.
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Availability of data and materials
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Code availability
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References
Sacco RL, Kasner SE, Broderick JP, Caplan LR, Connors JJ, Culebras A, Elkind MS, George MG, Hamdan AD, Higashida RT, Hoh BL, Janis LS, Kase CS, Kleindorfer DO, Lee JM, Moseley ME, Peterson ED, Turan TN, Valderrama AL, Vinters HV, American Heart Association Stroke Council, Council on Cardiovascular Surgery and Anesthesia, Council on Cardiovascular Radiology and Intervention, Council on Cardiovascular and Stroke Nursing, Council on Epidemiology and Prevention, Council on Peripheral Vascular Disease, Council on Nutrition, Physical Activity and Metabolism (2013) An updated definition of stroke for the 21st century: a statement for healthcare professionals from the American Heart Association/American Stroke Association. Stroke 44(7):2064–2089. https://doi.org/10.1161/STR.0b013e318296aeca
Del Zoppo JD, Hallenbeck JM (2000) Advances in the vascular pathophysiology of ischemic stroke. Thromb Res 98(3):73–81
Frizzell JP (2005) Acute stroke: pathophysiology, diagnosis, and treatment. AACN Clin Issues 16(4):421–598
Deba P, Sharma S, Hassan KM (2010) Pathophysiologic mechanisms of acute ischemic stroke: an overview with emphasis on therapeutic significance beyond thrombolysis. Pathophysiology 17:197–218. https://doi.org/10.1016/j.pathophys.2009.12.001
Hachinski V, Iadecola C, Petersen C, Breteler MM, Nyenhuis DL, Black SE et al (2006) National institute of neurological disorders and stroke—Canadian stroke network vascular cognitive impairment harmonization standards. Stroke 37:2220–2241. https://doi.org/10.1161/01.STR.0000237236.88823.47
Taub E, Berman AJ (1963) Avoidance conditioning in the absence of relevant proprioceptive and exteroceptive feedback. J Comp Physiol Psychol 56:1012–1016
Wolf SL, Lecraw DE, Barton LA, Jann BB (1989) Forced use of hemiplegic upper extremities to reverse the effect of learned nonuse among chronic stroke and head-injured patients. Exp Neurol 104(2):125–132
Taub E, Miller NE, Novack TA, Cook IEW, Fleming WC, Nepomuceno CS (1993) Technique to improve chronic motor deficit after stroke. Arch Phys Med Rehabil 74(4):347–354
Etoom M, Hawamdeh M, Hawamdeh Z (2016) Constraint-induced movement therapy as a rehabilitation intervention for upper extremity in stroke patients: systematic review and meta-analysis. Int J Rehabil Res 39:197–210
Abdullahi A, Truijen S, Saeys W (2020) Neurobiology of recovery of motor function after stroke: the central nervous system biomarker effects of constraint-induced movement therapy. Neural Plast 2020:1–12. https://doi.org/10.1155/2020/9484298
Yadav RK, Sharma R, Borah D, Kothari SY (2016) Efficacy of modified constraint induced movement therapy in the treatment of hemiparetic upper limb in stroke patients: a randomized controlled trial. J Clin Diagn Res 10(11):YC01–YC05
Shi YX, Tian JH, Yang KH, Zhao Y (2011) Modified constraint-induced movement therapy versus traditional rehabilitation in patients with upper-extremity dysfunction after stroke: a systematic review and meta-analysis. Arch Phys Med Rehabil 92:972–982
Yu C, Zhang Y, Wang Y, Hou W, Liu S, Gao C, Wang C, Mo L, Wu J (2017) The effects of modified constraint-induced movement therapy in acute subcortical cerebral infarction. Front Hum Neurosci 11. https://doi.org/10.3389/fnhum.2017.00265
Kaplon RT, Prettyman MG, Kushi CL, Winstein CJ (2007) Six hours in the laboratory: quantification of practice time during constraint induced therapy. Clin Rehabil 21(10):950–958
Stock G, Thrane G, Askim T (2015) Norwegian constraint induced therapy multisite trial: adherence to treatment protocol applied early after stroke. J Rehabil Med 47(9):816–823
Abdullahi A (2014) Is time spent using constraint induced movement therapy an appropriate measure of dose? A critical literature review. Int J Ther Rehabil 21(3):140–146
Schröder J, Truijen S, Van Criekinge T, Saeys W (2019) Feasibility and effectiveness of repetitive gait training early after stroke: a systematic review and meta-analysis. J Rehabil Med 51:78–88
Birkenmeier RL, Prager EM, Lang CE (2010) Translating animal doses of task-specific training to people with chronic stroke in 1-hour therapy sessions: a proof-of-concept study. Neurorehabil Neural Repair 4(7):620–635
Liberati A, Altman DG, Tetzlaff J, Mulrow C, Gøtzsche PC, Ioannidis JPA, Clarke M, Devereaux PJ, Kleijnen J, Moher D (2009) The PRISMA statement for reporting systematic reviews and meta-analyses of studies evaluate health care interventions: explanation and elaboration. PLoS Med 6:e1000100
Ouzzani M, Hammady H, Fedorowicz Z, Elmagarmid A (2016) Rayyan - a web and mobile application for systematic reviews. Syst Rev 5(1):2. https://doi.org/10.1186/s13643-016-0384-4
Law HK, Cheung CY, Ng HY et al (2005) Chemokine upregulation in SARS coronavirus infected human monocyte derived dendritic cells. Blood 106:2366–2376
Council-NHaMR (2009) NHMRC levels of evidence and grades for recommendations for guideline developers. National Health and Medical Research Council, Canberra
Abdullahi A (2018) Effects of number of repetitions and number of hours of shaping practice during constraint-induced movement therapy: a randomized controlled trial. Neurol Res Int 2018:1–9. https://doi.org/10.1155/2018/5496408
Abdullahi A, Umar NA, Ushotanefe U, Abba MA, Akindele MO, Truijen S, Saeys W (2021) Effects of two different modes of tasks practice during lower limbs constraint-induced movement therapy in people with stroke: a randomized clinical trial. Neural Plast 2021:1–9. https://doi.org/10.1155/2021/6664058
Waddell KJ, Birkenmeier RL, Moore JL, Hornby TG, Lang CE (2014) Feasibility of high-repetition, tasks pecific training for individuals with upper-extremity paresis. Am J Occup Ther 68:444–453. https://doi.org/10.5014/ajot.2014.011619
Abdullahi A, Shehu S, Dantani BI (2014) Feasibility of high repetitions of tasks practice during constraint induced movement therapy in an acute stroke patient. Int J Ther Rehabil 21(4):190–195
Billinger SA, Guo LX, Pohl PS, Kluding PM (2010) Single limb exercise: pilot study of physiological and functional responses to forced use of the hemiparetic lower extremity. Top Stroke Rehabil 17(2):128–139. https://doi.org/10.1310/tsr1702-128
eSilva EMGS, Ribeiro TS, da Silva TCC, Costa MFP, Cavalcanti FADC, Lindquist ARR (2017) Effects of constraint-induced movement therapy for lower limbs on measurements of functional mobility and postural balance in subjects with stroke: a randomized controlled trial. Top Stroke Rehabil 24(8):555–561. https://doi.org/10.1080/10749357.2017.1366011
Danlami KA, Abdullahi A (2017) Remodelling the protocol of lower limb constraint-induced movement therapy: a pilot randomized controlled trial. Arch Physiother Glob Res 21(4):21–27
Spaccavento S, Cellamare F, Falcone R, Loverre A, Nardulli R (2017) Effect of subtypes of neglect on functional outcome in stroke patients. Ann Phys Rehabil Med 60(6):376–381. https://doi.org/10.1016/j.rehab.2017.07.245
Vermeer SE, Algra A, Franke CL, Koudstaal PJ, Rinkel GJE (2002) Long-term prognosis after recovery from primary intracerebral hemorrhage. Neuroloy 59(2):205–209
Andersen KK, Olsen TS, Dehlendorff C, Kammersgaard LP (2009) Hemorrhagic and ischemic strokes compared stroke severity, mortality, and risk factors. Stroke 40:2068–2072
Reinhart S, Schmidt L, Kuhn C, Rosenthal A, Schenk T, Keller I, Kerkhoff G (2012) Limb activation ameliorates body-related deficits in spatial neglect. Front Hum Neurosci 6:188. https://doi.org/10.3389/fnhum.2012.00188
Stein MS, Kilbride C, Reynolds FA (2016) What are the functional outcomes of right hemisphere stroke patients with or without hemi-inattention complications? A critical narrative review and suggestions for further research. Disabil Rehabil 8(4):315–328
Mohr B, MacGregor LJ, Difrancesco S, Harrington K, Pulvermüller F, Shtyrov Y (2016) Hemispheric contributions to language reorganisation: an MEG study of neuroplasticity in chronic post stroke aphasia. Neuropsychologia 93:413–424
Maeshima S, Toshiro H, Sekiguchi E, Okita R, Yamaga H, Ozaki F et al (2002) Transcortical mixed aphasia due to cerebral infarction in left inferior frontal lobe and temporo-parietal lobe. Neuroradiology 44:133–137
Menezes K, Faria CD, Scianni AA, Avelino PR, Faria-Fortini I, Teixeira-Salmela LF (2017) Previous lower limb dominance does not affect measures of impairment and activity after stroke. Eur J Phys Rehabil Med 53(1):24–31. https://doi.org/10.23736/S1973-9087.16.04349-5
Nam HUK, Huh JS, Yoo JN, Hwang JM, Lee BJ, Min Y-S, Kim C-H, Jung T-D (2014) Effect of dominant hand paralysis on quality of life in patients with subacute stroke. Ann Rehabil Med 38(4):450–457. https://doi.org/10.5535/arm.2014.38.4.450
Nijland R, Kwakkel G, Bakers J, van Wegen E (2011) Constraint-induced movement therapy for the upper paretic limb in acute or sub-acute stroke: a systematic review. Int J Stroke 6(5):425–433
Kleim JA, Barbay S, Nudo RJ (1998) Functional reorganization of the rat motor cortex following motor skill learning. J Neurophysiol 80(6):3321–3325
Boyd, Winstein CJ (2006) Explicit information interferes with implicit motor learning of both continuous and discrete movement tasks after stroke. J Neurol Phys Ther 30(2):46–57
Carey JR, Kimberley TJ, Lewis SM, Auerbach EJ, Dorsey L, Rundquist P, Ugurbil K (2002) Analysis of fMRI and finger tracking training in subjects with chronic stroke. Brain 125(Pt 4):773–788
Nudo RJ, Milliken GW (1996) Reorganization of movement representations in primary motor cortex following focal ischemic infarcts in adult squirrel monkeys. J Neurophysiol 75(5):2144–2149
Huang YH, Wu CY, Hsieh YW, Lin KC (2010) Predictors of change in quality of life after distributed constraint-induced therapy in patients with chronic stroke. Neurorehabil Neural Repair 24(6):559–566. https://doi.org/10.1177/1545968309358074
Kelly KM, Borstad AL, Kline D, Gauthier LV (2018) Improved quality of life following constraint-induced movement therapy is associated with gains in arm use, but not motor improvement. Top Stroke Rehabil 25(7):467–474. https://doi.org/10.1080/10749357.2018.1481605
Bagley P, Hudson M, Green J, Forster A, Young J (2009) Do physiotherapy staff record treatment time accurately? An observational study. Clin Rehabil 23(9):841–845
Taub E, Lum PS, Hardin P, Mark VW, Uswatte G (2005) AutoCITE: automated delivery of CI therapy with reduced effort by therapists. Stroke 36(6):1301–1304. https://doi.org/10.1161/01.STR.0000166043.27545.e8
Lum PS, Taub E, Schwandt D, Postman M, Hardin P, Uswatte G (2004) Automated constraint-induced therapy extension (AutoCITE) for movement deficits after stroke. J Rehabil Res Dev 41(3A):249–258. https://doi.org/10.1682/jrrd.2003.06.0092
Borstad AL, Crawfis R, Phillips K, Lowes LP, Maung D, McPherson R, Siles A, Worthen-Chaudhari L, Gauthier LV (2018) In-home delivery of constraint-induced movement therapy via virtual reality gaming. J Patient Cent Res Rev 5(1):6–17. https://doi.org/10.17294/2330-0698.1550
Lawrence ES, Coshall C, Dundas R, Stewart J, Rudd AG, Howard R, Wolfe CDA (2001) Estimates of the prevalence of acute stroke impairments and disability in a multiethnic population. Stroke 32:1279–1284
Acknowledgement
The authors would like to thank the authors of the studies included in the review for giving us further information that where necessary in this paper.
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All authors contributed to the study conception and design. Material preparation, data collection and analysis were performed by Auwal Abdullahi, Melda Soysal Tomruk, Steven Truijen and Wim Saeys. The first draft of the manuscript was written by Auwal Abdullahi, and all authors commented on the previous versions of the manuscript. All authors read and approved the final manuscript.
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Appendix
Appendix
PubMed search strategy
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(1)
Cerebrovascular disorders
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(2)
Stroke
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(3)
Cerebrovascular accident
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(4)
Cerebrovascular disease
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(5)
Hemiplegia
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(6)
Hemiparesis
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(7)
1 OR 2 OR 3 OR 4 OR 5 OR 6
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(8)
Forced use
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(9)
Constraint induced movement therapy
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(10)
Constraint induced movement therapy
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(11)
Tasks practice
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(12)
Shaping practice
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(13)
Motor rehabilitation
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(14)
8 OR 9 OR 10 OR 11 OR 12 OR 13
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(15)
7 and 14
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(16)
Motor Function
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(17)
Motor impairment
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(18)
Real world arm use
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(19)
Quality of movement
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(20)
Quantity of movement
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(21)
16 OR 17 OR 18 OR 19 OR 20
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(22)
15 AND 21
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Abdullahi, A., Candan, S.A., Soysal Tomruk, M. et al. Constraint-induced movement therapy protocols using the number of repetitions of task practice: a systematic review of feasibility and effects. Neurol Sci 42, 2695–2703 (2021). https://doi.org/10.1007/s10072-021-05267-2
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DOI: https://doi.org/10.1007/s10072-021-05267-2