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The association between the adrenergic hyperactivity and blood pressure values in people with multiple sclerosis

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Abstract

Objectives

To evaluate the evolution of adrenergic baroreflex sensitivity (BRSa) over 2-year follow-up and to investigate the effect of baseline BRSa indices on blood pressure values after 2 years in people with multiple sclerosis (pwMS).

Methods

The following data were analysed at baseline and after 2 years: BRSa measured with BRSa1, α-BRSa and β-BRSa, supine and tilted levels of epinephrine and norepinephrine, supine and tilted systolic and diastolic blood pressure levels.

Results

Compared to baseline values, there was no change in α-BRSa (6.96 ± 2.56 vs. 6.64 ± 2.24, p = 0.379) at month 24. α-BRSa at month 24 positively correlated with tilted levels of norepinephrine at month 24 (rp = 0.357, p = 0.005). Univariable linear regression analysis revealed that α-BRSa at baseline predicts the value of tilted systolic and diastolic blood pressure at month 24 (B = 2.724, 95% CI 1.357–4.091, p < 0.001 and B = 1.489, 95% CI 0.459–2.519, p = 0.005).

Conclusion

This study provides further evidence for possible role of α-BRSa as a marker of adrenergic hyperactivity in pwMS. These results may explain increased risk for cardiovascular diseases in pwMS.

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Funding

This study was funded by the Installation Research project 2622 of the Croatian Science Foundation.

Author information

Authors and Affiliations

  1. Department of Neurology, Referral Center for Autonomic Nervous System Disorders, University Hospital Center Zagreb, Kišpatićeva 12, HR-10000, Zagreb, Croatia

    Mario Habek, Luka Crnošija & Magdalena Krbot Skorić

  2. School of Medicine, University of Zagreb, Zagreb, Croatia

    Mario Habek, Dunja Pucić & Tomislav Mutak

  3. Department of Laboratory Diagnostics, University Hospital Centre Zagreb, Zagreb, Croatia

    Mila Lovrić

  4. Faculty of Electrical Engineering and Computing, University of Zagreb, Zagreb, Croatia

    Magdalena Krbot Skorić

Authors
  1. Mario Habek
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  2. Dunja Pucić
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  3. Tomislav Mutak
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  4. Luka Crnošija
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  5. Mila Lovrić
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  6. Magdalena Krbot Skorić
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Contributions

Study concept and design: Habek. Acquisition of data: Habek, Pucić, Mutak, Crnošija, Lovrić Krbot Skorić. Analysis and interpretation of data: Habek, Pucić, Mutak, Crnošija, Lovrić Krbot Skorić. Drafting of the manuscript: Habek, Krbot Skorić. Critical revision of the manuscript for important intellectual content: Habek, Pucić, Mutak, Crnošija, Lovrić Krbot Skorić. Administrative, technical and material support: Habek, Pucić, Mutak, Crnošija, Lovrić Krbot Skorić.

Corresponding author

Correspondence to Mario Habek.

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Conflict of interest

None of the authors have relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript. This includes employment, consultancies, honoraria, stock ownership or options, expert testimony, grants or patents received or pending, or royalties. No writing assistance was utilized in the production of this manuscript.

Ethical approval

All patients signed informed consent and the study was approved by Ethical Committees of the University Hospital Center Zagreb and the University of Zagreb, School of Medicine.

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Habek, M., Pucić, D., Mutak, T. et al. The association between the adrenergic hyperactivity and blood pressure values in people with multiple sclerosis. Neurol Sci 41, 3157–3164 (2020). https://doi.org/10.1007/s10072-020-04432-3

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  • DOI: https://doi.org/10.1007/s10072-020-04432-3

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