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Prevalence of dysphagia in a consecutive cohort of subjects with MS using fibre-optic endoscopy

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Abstract

Introduction

Multiple sclerosis (MS) refers to chronic inflammation of the central nervous system including the brain and spinal cord. Dysphagia is a symptom that represents challenges in clinical practice. The aim of the present study was to evaluate the prevalence of dysphagia in an Italian cohort of subjects with MS using the Dysphagia Outcome Severity Score (DOSS), based on fibre-optic endoscopy, and determine factors that correlate with the presence of swallowing problems.

Matherials and Methods

Data were collected in a multicentre study from a consecutive sample of MS patients, irrespective of self-reported dysphagia. The study included 215 subjects. Possible scores for DOSS range from 7 to 1, with 7 indicating normal swallowing.

Results

One hundred twenty-four (57.7%) subjects demonstrated abnormal swallowing and 57 (26.5%) of these had swallowing problems that required nutrition/diet modifications when evaluated objectively with fibre-optic endoscopy. Subjects with dysphagia were more severely disabled and more often had a progressive form of MS, compared to MS subjects with normal swallowing. In subjects with EDSS, < 4, 8 (13.3%), had a DOSS < 4. Seventy-five percent of subjects older than 60 years of age had dysphagia.

Conclusion

In this sample of MS patients, more nearly 60% showed swallowing problems.

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Funding

The study was funded by the Italian MS Society Research Foundation.

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Authors and Affiliations

  1. Department of Rehabilitation, “M.L. Novarese” Hospital, Moncrivello, VC, Italy

    C. Solaro & G. Gamberini

  2. Neurorehabilitation Unit, IRCCS Santa Lucia, Rome, Italy

    A. Cuccaro & M. G. Grasso

  3. Department “GF Ingrassia”, University of Catania, Catania, Italy

    F. Patti & E. D’Amico

  4. IRCCS Mondino Foundation, Pavia, Italy

    R. Bergamaschi & E. Berra

  5. Neurology Unit, Department Head and Neck, ASL3 Genovese, Genoa, Italy

    A. Giusti

  6. Biostatistic Unit, Dept of Public Health Experimental and Forensic Medicine, Pavia, Italy

    C. Rezzani

  7. Italian MS Society Research Foundation, Genoa, Italy

    M. Messmer Uccelli

Authors
  1. C. Solaro
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  2. A. Cuccaro
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  3. G. Gamberini
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  4. F. Patti
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  5. E. D’Amico
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  6. R. Bergamaschi
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  7. E. Berra
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  8. A. Giusti
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  9. C. Rezzani
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  10. M. Messmer Uccelli
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  11. M. G. Grasso
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Corresponding author

Correspondence to C. Solaro.

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The authors declare that they have no conflict of interest.

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All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.

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Informed consent was obtained from all individual participants included in the study.

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Solaro, C., Cuccaro, A., Gamberini, G. et al. Prevalence of dysphagia in a consecutive cohort of subjects with MS using fibre-optic endoscopy. Neurol Sci 41, 1075–1079 (2020). https://doi.org/10.1007/s10072-019-04198-3

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  • DOI: https://doi.org/10.1007/s10072-019-04198-3

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