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Anti-GABAB receptor encephalitis in a patient with gastric adenocarcinoma

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Abstract

Anti-γ-aminobutyric acid-B (GABAB) receptor encephalitis is an autoimmune encephalitis associated with antibodies against neuronal cell surface antigens, which are primarily observed with small-cell lung cancer, melanoma, and thymoma. Here, we first report a case on the association between a relatively frequent cancer, gastric adenocarcinoma (GAC), and a rare GABAB receptor antibody limbic encephalitis. The patient was treated with immunotherapy and combined-drug chemotherapy, which were partially effective in terms of stabilizing the tumor and relieving neurological symptoms. This report indicates that, when patients present with GABAB receptor antibody limbic encephalitis, regular and broad screening for tumors including gastric adenocarcinoma should also be considered.

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Funding

This research was supported by the National Science Foundation of China (No. 81703842), Key Research and Development Projects of Shaanxi Provincial (No. S2018-YF-YBSF-0293), and Project of Science and Technology for Social Development in Shaanxi Province(2016SF-160).

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Author notes

  1. Xiaotao Jia and Yanfang Pan contributed equally to this work.

Authors and Affiliations

  1. Department of Neurology, The Affiliated Xi’an Central Hospital of Xi’an Jiaotong University College of Medicine, Xi’an, 710003, Shaanxi, People’s Republic of China

    Xiao-Tao Jia, Zhengli Di, Naibing Gu & Zhiqin Liu

  2. Department of Physiology and Pathophysiology, Cardiovascular Research Center, Xi’an Jiaotong University School of Medicine, Xi’an, 710061, Shaanxi, People’s Republic of China

    Xiao-Tao Jia & Yu-Ming Kang

  3. Department of Pathology, Shaanxi University of Chinese Medicine, Xianyang, 712046, Shaanxi, People’s Republic of China

    Yanfang Pan

Authors
  1. Xiao-Tao Jia
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  2. Yanfang Pan
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  3. Zhengli Di
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  4. Naibing Gu
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  5. Zhiqin Liu
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  6. Yu-Ming Kang
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Corresponding authors

Correspondence to Xiao-Tao Jia or Yu-Ming Kang.

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The authors declare that they have no conflict of interest.

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Jia, XT., Pan, Y., Di, Z. et al. Anti-GABAB receptor encephalitis in a patient with gastric adenocarcinoma. Neurol Sci 39, 1981–1984 (2018). https://doi.org/10.1007/s10072-018-3536-6

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  • DOI: https://doi.org/10.1007/s10072-018-3536-6

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