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RETRACTED ARTICLE: Gene expression profiling analysis of locus coeruleus in idiopathic Parkinson’s disease by bioinformatics

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This article was retracted on 17 August 2015

Abstract

This study aimed to explore the underlying molecular mechanisms of idiopathic Parkinson’s disease (IPD) by bioinformatics analysis. Gene expression profile GSE34516 was downloaded from the Gene Expression Omnibus. Eight locus coeruleus post-mortem tissue samples derived from four IPD patients and four neurological healthy controls were used to identify the differentially expressed genes (DEGs) by paired t test. Based on the DEGs, principal components were analyzed. The Gene Ontology functional and Kyoto Encyclopedia of Genes and Genomes pathway analysis of the genome microarray data were then performed. Finally, protein–protein interaction (PPI) network of the DEGs was constructed. Total 261 DEGs including 195 up-regulated and 66 down-regulated DEGs were identified. Intracellular protein transport and RNA splicing via transesterification reactions were selected as the most two significantly enriched functions. Mismatch repair, N-glycan biosynthesis, spliceosome and nucleotide excision repair were the significantly enriched pathways. In the PPI network, CTSS, CD53, IGSF6, PTPRC and LAPTM5 were the hub nodes. Intracellular protein transport and RNA splicing via transesterification reactions were closely associated with IPD. The DEGs, such as CX3CR1, SLC5A7, CD53 and PTPRC may be the potential targets for IPD diagnosis and treatment.

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Acknowledgments

We wish to express our warm thanks to the Fund supports from Shandong Province Natural Science Foundation of China (ZR2010CL018) and National Natural Science Fund (51273033, 81202502).

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Authors and Affiliations

  1. China Shandong Provincial Engineering Laboratory of New Pharmaceutical Excipients, Sustained and Controlled Release Technology, College of Medicine and Nursing, Dezhou University, Dezhou city, 253023, Shandong, China

    Shuqin Cui, Hanwen Sun, Xiangling Gu, Yancong Zhang, Pingxuan Dong, Chunhua Fu & Chao Zhu

  2. Department of Neurobiology, Capital Medical University, Beijing, 100069, China

    E. Lv

  3. Department of medicine, Dezhou University, No. 566, West Daxue Road, Decheng District, Dezhou city, 253023, Shandong, China

    Hanwen Sun

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  1. Shuqin Cui
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  2. Hanwen Sun
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  3. Xiangling Gu
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  4. E. Lv
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  5. Yancong Zhang
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  6. Pingxuan Dong
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  7. Chunhua Fu
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  8. Chao Zhu
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Correspondence to Hanwen Sun.

Additional information

The Publisher and Editor retract this article in accordance with the recommendations of the Committee on Publication Ethics (COPE). After a thorough investigation we have strong reason to believe that the peer review process was compromised.

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Cui, S., Sun, H., Gu, X. et al. RETRACTED ARTICLE: Gene expression profiling analysis of locus coeruleus in idiopathic Parkinson’s disease by bioinformatics. Neurol Sci 36, 97–102 (2015). https://doi.org/10.1007/s10072-014-1889-z

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  • DOI: https://doi.org/10.1007/s10072-014-1889-z

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