Skip to main content

Advertisement

SpringerLink
Log in

Unilateral headache with bilateral internal ophthalmoplegia

  • Case Report
  • Published:
Neurological Sciences Aims and scope Submit manuscript

Abstract

We describe the case of a young woman suffering from migraine. After some years, the headache started to be accompanied by internal ophthalmoplegia. Mydriasis was unilateral and after a few months became bilateral. The ophthalmoplegic migraine is a rare type of headache and it is characterized by paresis of one or more of the third, fourth or sixth cranial nerves. Migraine attacks associated with mydriasis (internal ophthalmoplegia) are extremely rare. Triptan therapy resolved mydriasis, but not the headache.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. Levin M, Ward TN (2004) Ophthalmoplegic migraine. Curr Pain Headache Rep 8:306–309

    Article  PubMed  Google Scholar 

  2. Arasho BD (2009) Ophthalmoplegic migraine in a 15-year-old Ethiopian: case report and literature review. J Headache Pain 10:45–49

    Article  PubMed  Google Scholar 

  3. Bek S, Genc G, Demirkaya S, Eroglu E, Odabasi Z (2009) Ophthalmoplegic migraine. The Neurologist 15:147–149

    Article  PubMed  Google Scholar 

  4. McMillan HJ, Keene DL, Jacob P, Humphreys P (2007) Ophthalmoplegic migraine: inflammatory neuropathy with secondary migraine? Can J Neurol Sci 34:349–355

    PubMed  CAS  Google Scholar 

  5. Headache Classification Subcommittee of the International Headache Society (2004) The international classification of headache disorders, 2nd edn. Cephalalgia 24(S1):1–160

  6. Maggioni F, Mainardi F, Malvindi ML, Zanchin G (2010) The borderland of migraine with aura: episodic unilateral mydriasis. J Headache Pain. [Epub ahead of print]

  7. Barriga FJ, López de Silanes C, Gili P, Pareja J (2010) Ciliary ganglioplegic migraine: migraine-related prolonged mydriasis. Cephalalgia. [Epub ahead of print]

  8. Woods D, O’Connor PS, Fieming R (1984) Episodic unilateral mydriasis and migraine. Am J Ophthalmol 98:229–234

    PubMed  CAS  Google Scholar 

  9. Jacobson DM (1995) Benign episodic unilateral mydriasis. Clinical characteristics. Ophthalmology 102:1623–1627

    PubMed  CAS  Google Scholar 

  10. Edelson RN, Levy DE (1974) Transient benign unilateral papillary dilation in young adults. Arch Neurol 31:12–14

    Article  PubMed  CAS  Google Scholar 

  11. Gilbert ME, Friedman D (2007) Migraine and anisocoria. Surv Ophthalmol 52:209–212

    Article  PubMed  Google Scholar 

  12. Evans RW, Jacobson DM (2003) Transient anisocoria in migraineur. Headache 43:416–418

    Article  PubMed  Google Scholar 

  13. Choi JY, Jang SII, Ho MP, Jo KB, Lee DH (2007) Ophthalmoplegic migraine with alternating unilateral and bilateral internal ophthalmoplegia. Headache 47:726–728

    PubMed  Google Scholar 

  14. van Engelen BGM, Renier WO, Gabreels FJM, Cruysberg HRM (1991) Bilateral episodic mydriasis as a migraine equivalent in childhood: a case report. Headache 31:375–377

    Article  PubMed  Google Scholar 

  15. De Marinis M, Assenza S, Carletto F (1998) Oculosympathetic alterations in migraine patients. Cephalalgia 18:77–84

    Article  PubMed  Google Scholar 

  16. Crevits L, Verschelde H, Casselman J (2006) Ophthalmoplegic migraine: an unresolved problem. Cephalalgia 26:1255–1259

    Article  PubMed  CAS  Google Scholar 

  17. Fajardo RV (1981) Neuro-ophthalmological complications of contraceptive pills. Philipp J ophthalmol 13:19–21

    PubMed  CAS  Google Scholar 

  18. Lal V, Sahota P, Singh P, Gupta A, Prabhakar S (2009) Ophthalmoplegia with migraine in adults: is it ophthalmoplegic migraine? Headache 49:838–850

    Article  PubMed  Google Scholar 

  19. Leone M, Grazzi L, Moschiano F, Bussone G (1994) lnternal ophthalmoplegia associated with migraine attacks. Cephalalgia 14:461–462

    Article  PubMed  CAS  Google Scholar 

  20. Drouet A, De Carvalho A, Mage F, Guilloton L, Felten D (2008) Pupille tonique d’adie et migraine: une association fortuite? J Fr Ophtalmol 31:e5

    Article  PubMed  CAS  Google Scholar 

  21. Balaguer-Santamaria JA, Escofet-Soteras C, Chumbe-Soto G, Escribano-Subias J (2000) Midriasis unilateral benigna episódica. Caso clínico en un niño. Rev Neurol 31(8):743–745

    PubMed  CAS  Google Scholar 

  22. Gupta R, Bhatia MS (2006) A report of cranial autonomic symptoms in migraineurs. Cephalalgia 27:22–28

    Article  Google Scholar 

  23. Gendolla A (2008) Early treatment in migraine: how strong is the current evidence? Cephalalgia 28(2):28–35

    Article  PubMed  Google Scholar 

Download references

Conflict of interest

The authors have no conflicts of interest.

Author information

Authors and Affiliations

  1. Division of Neurology, Department of Specialty Medicine, Azienda ULSS 15 “Alta Padovana”, Cittadella Hospital, Padova, Italy

    Marco Simonetto

  2. Division of Neurology, Department of Specialty and Rehabilitation Medicine, “Santa Maria degli Angeli” Hospital, Pordenone, Italy

    Luca Zanet, Francesca Capozzoli, Andrea Gelli & Giovanni Masè

Authors
  1. Marco Simonetto
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Luca Zanet
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Francesca Capozzoli
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Andrea Gelli
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Giovanni Masè
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Marco Simonetto.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Simonetto, M., Zanet, L., Capozzoli, F. et al. Unilateral headache with bilateral internal ophthalmoplegia. Neurol Sci 33, 1185–1187 (2012). https://doi.org/10.1007/s10072-011-0883-y

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s10072-011-0883-y

Keywords

Search

Navigation