Skip to main content

Advertisement

SpringerLink
Log in

The magnetic resonance spectroscopy findings of extrapontine myelinolysis in a patient with acute lymphoblastic leukemia

  • Case Report
  • Published:
Neurological Sciences Aims and scope Submit manuscript

Abstract

The magnetic resonance (MR) spectroscopy findings of extrapontine myelinolysis have been rarely reported. Herein, we present MR spectroscopy findings as well as the conventional MR and diffusion MR findings of an acute lymphoblastic leukemia patient with extrapontine myelinolysis. Advanced MR imaging including diffusion-weighted imaging and MR spectroscopy may be helpful to exclude other pathologies in the differential diagnosis and make the diagnosis when there is a diagnostic difficulty on cases clinically suspicious for extrapontine myelinolysis.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1
Fig. 2
Fig. 3

Similar content being viewed by others

References

  1. Filippatos TD, Milionis HJ, Elisaf MS (2005) Alterations in electrolyte equilibrium in patients with acute leukemia. Eur J Haematol 75:449–460

    Article  PubMed  CAS  Google Scholar 

  2. Lim KH, Kim S, Lee YS, Kim KH, Kim J et al (2008) Central pontine myelinolysis in a patient with acute lymphoblastic leukemia after hematopoietic stem cell transplantation: a case report. J Korean Med Sci 23:324–327

    Article  PubMed  Google Scholar 

  3. Tarhan NC, Agildere AM, Benli US, Ozdemir FN, Aytekin C, Can U (2004) Osmotic demyelination syndrome in end-stage renal disease after recent hemodialysis: MRI of the brain. AJR Am J Roentgenol 182:809–816

    PubMed  Google Scholar 

  4. Tsutsumi S, Yasumoto Y, Ito M (2008) Central pontine and extrapontine myelinolysis in an infant associated with the treatment of craniopharyngioma: case report. Neurol Med Chir (Tokyo) 48:351–354

    Article  Google Scholar 

  5. Jacome DE (2011) Sound induced photisms in pontine and extrapontine myelinolysis. Clin Neurol Neurosurg 113:503–505

    Article  PubMed  Google Scholar 

  6. Jo YS, Han SD, Na SJ (2011) Central pontine myelinolysis presented after prophylactic cranial irradiation in small lung cancer. Neurol Sci (Epub ahead of print)

  7. Gocht A, Colmant HJ (1987) Central pontine and extrapontine myelinolysis: a report of 58 cases. Clin Neuropathol 6:262–270

    PubMed  CAS  Google Scholar 

  8. McNeill G, Halpenny D, Snow A, Geoghegan A, Torreggiani WC (2009) Extrapontine myelinolysis after correction of hyponatraemia presenting as generalised tonic seizures. Am J Emerg Med 27:243

    Article  PubMed  Google Scholar 

  9. Dolciotti C, Nuti A, Cipriani G, Borelli P, Baldacci F, Logi C, Bonuccelli U (2011) Cerebellar ataxia with complete clinical recovery and resolution of MRI lesions related to central pontine myelinolysis: case report and literature review. Case Rep Neurol 2:157–162

    Article  Google Scholar 

  10. Hazratji SMA, Kim RC, Lee SH, Marasigan AV (1983) Evoluation of pontine and extrapontine myelinolysis. J Compu Assist Tomogr 7:356–361

    Article  CAS  Google Scholar 

  11. Buis CI, Wijdicks EF (2002) Serial magnetic resonance imaging of central pontine myelinolysis. Liver Transpl 8:643–645

    Article  PubMed  Google Scholar 

  12. Cramer SC, Stegbauer KC, Schneider A, Mukai J, Maravilla KR (2001) Decreased diffusion in central pontine myelinolysis. AJNR Am J Neuroradiol 22:1476–1479

    PubMed  CAS  Google Scholar 

  13. Guo Y, Hu J, Lin W, Zheng KH (2006) Central pontine myelinolysis after liver transplantation: MR diffusion, spectroscopy and perfusion findings. Magn Reson Imaging 24:1395–1398

    Article  PubMed  Google Scholar 

  14. Smith JK, Londono A, Castillo M, Kwock L (2002) Proton magnetic resonance of brain-stem lesions. Neuroradiology 44:825–829

    Article  PubMed  CAS  Google Scholar 

  15. Karakas HM, Erdem G, Yakıncı C (2007) Osmotic demyelination syndrome in a 40-day-old infant. Diagn Interv Radiol 13:121–124

    PubMed  Google Scholar 

  16. Hedge AN, Mohan S, Lath N, Lim CC (2011) Differential diagnosis for bilateral abnormalities of the basal ganglia and thalamus. Radiographics 31:5–30

    Article  Google Scholar 

  17. Tallibert S, Guillevin R, Menuel C et al (2008) Brain lymphoma: usefulness of the magnetic resonance spectroscopy. J Neurooncol 86:225–229

    Article  Google Scholar 

  18. Harting I, Hartmann M, Jost G et al (2003) Differentiating primary central nervous system lymphoma from glioma in humans using localised proton magnetic resonance spectroscopy. Neurosci Lett 342:163–166

    Article  PubMed  CAS  Google Scholar 

  19. Tang YZ, Booth TC, Bhogal P, Malhotra A, Wilhelm T (2011) Imaging of primary central nervous system lymphoma. Clin Radiol 66:768–777

    Article  PubMed  CAS  Google Scholar 

  20. Erdag N, Bhorade RM, Alberico RA, Yousuf NP, Patel MR (2001) Primary lymphoma of the central nervous system: typical and atypical CT and MR imaging appearances. AJR Am J Roentgenol 176:1319–1326

    PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Radiology, Baskent University, Faculty of Medicine, Bahcelievler, 06490, Ankara, Turkey

    Hulya Aslan, Fuldem Y. Donmez & O. Koray Hekimoglu

  2. Department of Radiology, Northwestern Memorial Hospital, 676 St. Clair St. 800, 60611, Chicago, IL, USA

    Huseyin G. Tore

Authors
  1. Hulya Aslan
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Fuldem Y. Donmez
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. O. Koray Hekimoglu
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Huseyin G. Tore
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Fuldem Y. Donmez.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Aslan, H., Donmez, F.Y., Hekimoglu, O.K. et al. The magnetic resonance spectroscopy findings of extrapontine myelinolysis in a patient with acute lymphoblastic leukemia. Neurol Sci 33, 391–394 (2012). https://doi.org/10.1007/s10072-011-0729-7

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s10072-011-0729-7

Keywords

Search

Navigation