Abstract
Intracerebral hemorrhage (ICH) is the most serious complication of oral anticoagulant therapy (OAT), with mortality in excess of 50%. Major risk factors are advanced patient age, elevated systolic blood pressure, intensity of anticoagulation, and previous cerebral ischemia. A number of acute treatments are available, but all have significant side effects and no randomized clinical trials assessing clinical outcome have been performed. Future trials will have to address choice and dose of agent, the timing of its administration, and the risk of side effects.
Similar content being viewed by others
References
Hart RG, Aguilar MI (2008) Anticoagulation in atrial fibrillation: Selected controversies including optimal anticoagulation intensity, treatment of intracerebral hemorrhage. J Thromb Thrombolysis. 25:26–32
Hart RG, Tonarelli SB, Pearce LA (2005) Avoiding central nervous system bleeding during antithrombotic therapy: Recent data and ideas. Stroke 36:1588–1593
Berwaerts J, Dijkhuizen RS, Robb OJ, Webster J (2000) Prediction of functional outcome and in-hospital mortality after admission with oral anticoagulant-related intracerebral hemorrhage. Stroke 31:2558–2562
Steiner T, Rosand J, Diringer M (2006) Intracerebral hemorrhage associated with oral anticoagulant therapy: Current practices and unresolved questions. Stroke 37:256–262
Flibotte JJ, Hagan N, O’Donnell J et al (2004) Warfarin, hematoma expansion, and outcome of intracerebral hemorrhage. Neurology 63:1059–1064
Levine JM, Snider R, Finkelstein D et al (2007) Early edema in warfarin-related intracerebral hemorrhage. Neurocrit Care 7:58–63
Aguilar MI, Hart RG, Kase CS et al (2007) Treatment of warfarin-associated intracerebral hemorrhage: Literature review and expert opinion. Mayo Clin Proc 82:82–92
Author information
Authors and Affiliations
Corresponding author
Rights and permissions
About this article
Cite this article
Cavallini, A., Fanucchi, S. & Persico, A. Warfarin-associated intracerebral hemorrhage. Neurol Sci 29 (Suppl 2), 266–268 (2008). https://doi.org/10.1007/s10072-008-0959-5
Published:
Issue Date:
DOI: https://doi.org/10.1007/s10072-008-0959-5