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Inhibition of the lipogenesis in liver and adipose tissue of diet-induced obese C57BL/6 mice by feeding oleic acid-rich sesame oil

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Abstract

The effects of sesame oil (SO) on lipogenic gene expression and lipid metabolism were observed. One percent of SO was added into the high-fat diet (HFD) used to feed C57BL/6 male mice for 8 weeks. SO significantly lowered adipose tissue mass than that of the high-fat control group. In addition, serum and hepatic lipid contents were markedly lower than those of the high-fat control group. Especially, the ratio of HDL/LDL was much higher than that of the HFD group. The gene expression of key lipogenic enzymes, Ppar-γ, Srebp-1c, Scd-1, Fas, Acc, Lpl, and malic enzyme, was significantly downregulated in the liver and adipose tissue of mice fed sesame oil. This study suggests that high proportion of oleic acid in SO might be strongly associated with lowering serum and hepatic lipid profile and suppressing lipogenic gene expression.

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Authors and Affiliations

  1. Department of Food and Biotechnology, Korea University, Sejong, 339-700, Korea

    Jeong Hoon Pan, Mi Jeong Kim, Jun Ho Kim, Yun Jeong Cho, Sungjin Park & Young Jun Kim

  2. Department of Food Science and Biotechnology, Dongguk University, Seoul, 100-715, Korea

    Han-Seung Shin

  3. Department of Biology, Dongguk University, Seoul, 100-715, Korea

    Jung-Suk Sung

  4. Department of Life Sciences, College of BioNano Technology, Gachon University, Seongnam, Gyeonggi, 461-701, Korea

    Tae Sik Park

  5. Department of Biochemistry and Molecular Biology, Center for Chronic Metabolic Disease Research, Brain Korea 21 Project for Medical Sciences, Yonsei University College of Medicine, Seoul, 120-752, Korea

    Ho-Geun Yoon

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  1. Jeong Hoon Pan
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Correspondence to Young Jun Kim.

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Pan, J.H., Kim, M.J., Kim, J.H. et al. Inhibition of the lipogenesis in liver and adipose tissue of diet-induced obese C57BL/6 mice by feeding oleic acid-rich sesame oil. Food Sci Biotechnol 24, 1115–1121 (2015). https://doi.org/10.1007/s10068-015-0142-8

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  • DOI: https://doi.org/10.1007/s10068-015-0142-8

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