Skip to main content
SpringerLink
Log in

Extrusion process enhances the anti-inflammatory effect of Acanthopanax senticosus leaves

  • Research Article
  • Published:
Food Science and Biotechnology Aims and scope Submit manuscript

Abstract

The anti-inflammatory effects of Acanthopanax senticosus leaves (ASL) and the effects of extrusion were evaluated. ASL exhibited in vitro and in vivo antiinflammatory activities in experimental systems. Extrusion increased the effect of ASL. ASL reduced C48/80-induced histamine release from HMC-1 cells as well as in vivo model, suggesting that ASL induces mast cell stabilization and has an anti-histamine activity. The effects of ASL and extruded ASL (ASLE) on pro-inflammatory cytokine production were evaluated. ASL treatment reduced MCP- 1, TNF-α, and IL-1β mRNA expressions and decreased their protein levels in HMC-1 cells. Decreases in serum NO, MDA, and TNF-α levels were observed in acute inflammatory rats, and extrusion increased the effects of ASL in a dose-dependent manner. These data support pharmacological basis of ASL and the effect of extrusion for future treatment of inflammation.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

Refrerences

  1. Theoharides TC, Alysandratos KD, Angelidou A, Delivanis DA, Sismanopoulos N, Zhang B, Asadi S, Vasiadi M, Weng Z, Miniati A, Kalogeromitros D. Mast cells and inflammation. Biochim. Biophys. Acta 1822: 21–33 (2012)

    Article  CAS  Google Scholar 

  2. Blue ML, Conrad P, Webb DL, Sarr T, Macaro M. Interacting monocytes and synoviocytes induce adhesion molecules by a cytokine-regulated process. Lymphokine Cytokine Res. 12: 213–218 (1993)

    CAS  Google Scholar 

  3. Huang L, Zhao H, Huang B, Zheng C, Peng W, Qin L. Acanthopanax senticosus: Review of botany, chemistry and pharmacology. Pharmazie 66: 83–97 (2011)

    CAS  Google Scholar 

  4. Lin QY, Jin LJ, Ma YS, Shi M, Xu YP. Acanthopanax senticosus inhibits nitric oxide production in murine macrophages in vitro and in vivo. Phytother. Res. 21: 879–883 (2007)

    Article  Google Scholar 

  5. Lee SH, Oh HY, Leem JY, Yoon S. Antioxidant and NO-scavenging activities of Acanthopanax senticosus var. subinermis leaf extracts prepared using ethanol and extrusion processing. Food Sci. Biotechnol. 18: 1124–1131 (2009)

    Google Scholar 

  6. Ha DC, Lee JW, Ryu GH. Change in ginsenosides and maltol in dried raw ginseng during extrusion process. Food Sci. Biotechnol. 14: 63–67 (2005)

    Google Scholar 

  7. White BL, Howard LR, Prior RL. Polyphenolic composition and antioxidant capacity of extruded cranberry pomace. J. Agr. Food Chem. 58: 4037–4042 (2010)

    Article  CAS  Google Scholar 

  8. Shore PA. The chemical determination of histamine. Methods Biochem. Anal. (Suppl.): 89–97 (1971)

    Chapter  Google Scholar 

  9. Pfaffl MW. A new mathematical model for relative quantification in real-time RT-PCR. Nucleic Acids Res. 29: 2002–2007 (2001)

    Article  Google Scholar 

  10. Lorenz W, Reimann HJ, Barth H, Kusche J, Meyer R, Doenicke A, Hutzel M. A sensitive and specific method for the determination of histamine in human whole blood and plasma. Hoppe Seylers Z. Physiol. Chem. 353: 911–920 (1972)

    Article  CAS  Google Scholar 

  11. Chen M, Song F, Guo M, Liu Z, Liu S. Analysis of flavonoid constituents from leaves of Acanthopanax senticosus harms by electrospray tandem mass spectrometry. Rapid Commun. Mass Spectrom. 16: 264–271 (2002)

    Article  CAS  Google Scholar 

  12. Bronner C, Wiggins C, Monté D, Märki F, Capron A, Landry Y, Franson RC. Compound 48/80 is a potent inhibitor of phospholipase C and a dual modulator of phospholipase A2 from human platelet. Biochim. Biophys. Acta 920: 301–305 (1987)

    Article  CAS  Google Scholar 

  13. Saperstein S, Chen L, Oakes D, Pryhuber G, Finkelstein J. IL-1β augments TNF-α-mediated inflammatory responses from lung epithelial cells. J. Interferon Cytokine Res. 29: 273–284 (2009)

    Article  CAS  Google Scholar 

  14. Lee SA, Fitzgerald SM, Huang SK, Li C, Chi DS, Milhorn DM, Krishnaswamy G. Molecular regulation of interleukin-13 and monocyte chemoattractant protein-1 expression in human mast cells by interleukin-1β. Am. J. Respir. Cell Mol. Biol. 31: 283–291 (2004)

    Article  CAS  Google Scholar 

  15. Conti P, Boucher W, Letourneau R, Feliciani C, Reale M, Barbacane RC, Vlagopoulos P, Bruneau G, Thibault J, Theoharides TC. Monocyte chemotactic protein-1 provokes mast cell aggregation and [3H]5HT release. Immunol. 86: 434–440 (1995)

    CAS  Google Scholar 

  16. Park HH, Lee S, Son HY, Park SB, Kim MS, Choi EJ, Singh TS, Ha JH, Lee MG, Kim JE, Hyun MC, Kwon TK, Kim YH, Kim SH. Flavonoids inhibit histamine release and expression of proinflammatory cytokines in mast cells. Arch. Pharm. Res. 31: 1303–1311 (2008)

    Article  CAS  Google Scholar 

  17. Jung HJ, Nam JH, Choi J, Lee KT, Park HJ. Antiinflammatory effects of chiisanoside and chiisanogenin obtained from the leaves of Acanthopanax chiisanensis in the carrageenan- and Freunďs complete adjuvant-induced rats. J. Ethnopharmacol. 97: 359–367 (2005)

    Article  CAS  Google Scholar 

  18. Shi M. Kuo C, Chiang W. Effects of drying and extrusion on colour, chemical composition, antioxidant activities and mitogenic response of spleen lymphocytes of sweet potatoes. Food Chem. 117: 114–121 (2009)

    Article  Google Scholar 

  19. Khanal RC, Howard LR, Prior RL. Procyanidin content of grape seed and pomace, and total anthocyanin content of grape pomace as affected by extrusion processing. J. Food Sci. 74: H174–H182 (2009)

    Article  CAS  Google Scholar 

  20. Gu L, House SE, Rooney LW, Prior RL. Sorghum extrusion increases bioavailability of catechins in weanling pigs. J. Agr. Food Chem. 56: 1283–1288 (2008)

    Article  CAS  Google Scholar 

  21. Guzik TJ, Korbut R, Adamek-Guzik T. Nitric oxide and superoxide in inflammation and immune regulation. J. Physiol. Pharmacol. 54: 469–487 (2003)

    CAS  Google Scholar 

  22. Ohta Y, Kobayashi T, Nishida K, Ishiguro I. Relationship between changes of active oxygen metabolism and blood flow and formation, progression, and recovery of lesions is gastric mucosa of rats with a single treatment of compound 48/80, a mast cell degranulator. Dig. Dis. Sci. 42: 1221–1232 (1997)

    Article  CAS  Google Scholar 

  23. Matata BM, Galiñanes M. Peroxynitrite is an essential component of cytokines production mechanism in human monocytes through modulation of nuclear factor-kappa B DNA binding activity. J. Biol. Chem. 277: 2330–2335 (2002)

    Article  CAS  Google Scholar 

  24. García-Mediavilla V, Crespo I, Collado PS, Esteller A, Sánchez-Campos S, Tuñón MJ, González-Gallego J. The anti-inflammatory flavones quercetin and kaempferol cause inhibition of inducible nitric oxide synthase, cyclooxygenase-2 and reactive C-protein, and down-regulation of the nuclear factor kappaB pathway in Chang liver cells. Eur. J. Pharmacol. 557: 221–229 (2007)

    Article  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. College of Korean Medicine, Semyung University, Chungbuk, 390-71, Korea

    Kang-Hyun Leem & Sena Lee

  2. Department of Food & Biotechnology, Hanseo University, Seosan, Chungnam, 356-706, Korea

    Hye Kyung Kim

Authors
  1. Kang-Hyun Leem
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Sena Lee
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Hye Kyung Kim
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Hye Kyung Kim.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Leem, KH., Lee, S. & Kim, H.K. Extrusion process enhances the anti-inflammatory effect of Acanthopanax senticosus leaves. Food Sci Biotechnol 23, 911–916 (2014). https://doi.org/10.1007/s10068-014-0122-4

Download citation

  • Received:

  • Revised:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s10068-014-0122-4

Keywords

Search

Navigation