Presentation
A 14-year-old boy was referred to a rheumatology clinic with left elbow pain, swelling, and stiffness for the past 6 months. His pain aggravated at night and was relieved with ibuprofen. He gave no history of polyarthralgia or morning stiffness. On examination, he had a diffuse swelling around the posterolateral aspect of the elbow. He had an effusion and a fixed flexion deformity of 40 degrees with further flexion to 120 degrees.
Radiographs of the distal humerus showed a well-defined radiolucent lesion with central calcification and adjacent diffuse sclerosis in the lateral aspect of the wall of the olecranon fossa (Fig. 1a). Multidetector computed tomography (MDCT) showed a cortical-based lesion with an intraarticular component and dense central mineralization (Fig. 1b). Post-contrast T1 fat-suppressed (FS) magnetic resonance images (MRI) demonstrated enhancement along the margins of the lesion, intense reactive synovitis, and joint effusion (Fig. 1c). The imaging findings were suggestive of an osteoid osteoma (OO). His hand radiographs did not show any evidence of periarticular osteopenia commonly seen in inflammatory arthritides. Radiographs of his lumbar spine did not show evidence of syndesmophyte/sacroiliitis.
Spontaneous onset symptoms with the absence of morning stiffness, normal blood counts, ESR, CRP, RA factor, ANA, ACCP, uric acid, and imaging ruled out inflammatory, infective, and traumatic causes of monoarthritis. The patient’s characteristic history and the nidus on imaging were suggestive of an OO. We performed an image-guided excision biopsy with complete resolution of pain, stiffness, and synovitis. Microbiological examination of the bone, synovium, and fluid (normal bacteria and acid-fast bacilli) showed no growth. Histopathological examination (Fig. 1d) confirmed the diagnosis.
Discussion
OO is a self-limiting benign bone-forming tumor mostly seen in the second decade of life [1]. Prostaglandin synthesis has been shown to occur in the nidus and this is thought to be the reason for the relief of symptoms with non-steroidal anti-inflammatory drugs (NSAIDS) [2]. The intraarticular part of the OO is known to cause intense synovitis in the elbow and hip as most of the epiphysis even the metaphysis is localized within the synovial cavity [3]. This can mimic monoarthritis like in this case causing stiffness due to a mechanical block.
Although spontaneous regression over many years has been reported [4], most cases require surgery due to severe pain. The lesion could be ablated using a radiofrequency probe or excised using percutaneous or open methods [5].
If an adolescent presents with monoarthritis, inflammatory causes (rheumatoid arthritis, undifferentiated arthritis, and seronegative spondyloarthropathies), crystal deposition diseases (gout and pseudogout), infections (tuberculosis, Brodie’s abscess, and septic arthritis), trauma, and neoplastic causes like OO should be considered.
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P, M.J., Kandathil, J.C., Jalal, M.J.A. et al. Osteoid osteoma masquerading monoarthritis of the elbow. Clin Rheumatol 41, 313–314 (2022). https://doi.org/10.1007/s10067-021-05883-5
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DOI: https://doi.org/10.1007/s10067-021-05883-5