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Association between leptin and IL-6 concentrations with cardiovascular risk in patients with rheumatoid arthritis

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Abstract

Pro-inflammatory cytokines such as leptin and IL-6 play an important role in the development of cardiovascular risk. Determine the relationship between leptin and IL-6 concentrations with cardiovascular risk in patients with rheumatoid arthritis. We determined IL-6 and leptin levels in 77 patients with the diagnosis of rheumatoid arthritis. The cardiovascular risk was calculated using the modified Framingham scale. Statistical analysis was performed using SPSS 22 considering a significant p < 0.05. Serum leptin concentrations and cardiovascular risk (CVR) factors were compared and found that there was a significant difference between higher leptin values and disease activity (p 0.047), obesity (p 0.038), positive rheumatoid factor (p 0.009), tobacco (p 0.009), and metabolic syndrome (p 0.001). Likewise, a significant relationship was found between lower leptin concentrations and hydroxychloroquine consumption (p = 0.023). We found significant difference between IL-6 concentrations and disease activity (p 0.028), hypertriglyceridemia (p 0.023), LDL-C (p 0.029), and smoking (0.005). Similarly, an association between hydroxychloroquine consumption and low concentrations of IL-6 was found (p 0.005). Framingham CVR was calculated and the result obtained was multiplied by 1.5. The 35.2% of the population studied had a low Framingham CVR, 38.9% moderate, and 25.9% presented a high risk. We compared the level of CVR and serum leptin and IL-6 concentrations, finding that the highest CVR was the leptin and IL-6 values. There is a positive association between CVR and serum leptin concentrations. It is also significantly associated with traditional and non-traditional risk factors.

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Acknowledgements

The authors gratefully acknowledge the support from the UJAT-IN-2015-05.

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Authors and Affiliations

  1. Instituto Mexicano del Seguro Social, Mexico City, Tabasco, Mexico

    José Antonio De Jesús Batún-Garrido

  2. Universidad Juárez Autónoma de Tabasco, Villahermosa, Mexico

    Marisol Salas-Magaña & Isela Esther Juárez-Rojop

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  1. José Antonio De Jesús Batún-Garrido
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  2. Marisol Salas-Magaña
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  3. Isela Esther Juárez-Rojop
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Corresponding author

Correspondence to José Antonio De Jesús Batún-Garrido.

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This study was performed with the prior approval of the Bioethics Committee of the Hospital and according to the guidelines of the Helsinki Declaration.

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Batún-Garrido, J.A.D., Salas-Magaña, M. & Juárez-Rojop, I.E. Association between leptin and IL-6 concentrations with cardiovascular risk in patients with rheumatoid arthritis. Clin Rheumatol 37, 631–637 (2018). https://doi.org/10.1007/s10067-017-3897-x

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  • DOI: https://doi.org/10.1007/s10067-017-3897-x

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