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Multiple values of 18F-FDG PET/CT in idiopathic inflammatory myopathy

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Abstract

This study aimed to investigate the multiple values of 18F-FDG PET/CT in detecting malignant tumors, evaluating myopathy, and determining interstitial lung disease in patients with idiopathic inflammatory myopathy (IIM). We retrospectively analyzed the data of 38 patients who were examined by 18F-FDG PET/CT and eventually diagnosed as IIM. We also collected the data of another 22 cases with negative PET/CT as the control. Pulmonary HRCT images were acquired simultaneously with regular 18F-FDG PET/CT imaging for each patient. Image analysis included the presence of malignant lesions, muscular FDG uptake, and interstitial lung disease and its imaging features. IIM was classified into polymyositis (PM), classic dermatomyositis (CDM), and clinical amyopathic dermatomyositis (CADM). All suspected malignant lesions were confirmed by histopathological examination. Interstitial lung disease was diagnosed by HRCT. Rapidly progressive interstitial lung disease (RP-ILD) was determined according to clinical follow-ups. The significance of 18F-FDG PET/CT in the detection of malignancy, observation of activity of myopathy, and determination of interstitial lung disease in IIM patients was explored based on the final clinical diagnosis. In the 38 patients with IIM, 3 cases were classified as PM, 18 as CDM, and 17 as CADM. PET/CT correctly detected 7 cases (18.4%) of malignant tumors, and all of which were found in CDM and PM patients. The muscular FDG uptake in IIM patients was higher than the control population, and it was higher in patients with myopathy (including PM and CDM) than in patients with CADM. The muscular FDG uptake in IIM patients was correlated with elevated serum creatine kinase level (r = 0.332, P = 0.042) and impaired muscle strength (r = −0.605, P < 0.001). Interstitial lung disease was detected by HRCT in 30 patients (78.9%), and 7 of them were eventually confirmed as RP-ILD, according to the clinical outcome. The FDG uptake in lung lesions of RP-ILD patients was higher than those with chronic interstitial lung diseases, even though no significant difference was found between the CT features of RP-ILD and chronic interstitial lung disease. When SUVmax ≥ 2.4 was employed as the threshold for RP-ILD prediction, the diagnostic efficiency was yield with a sensitivity of 100.0% (7/7), specificity of 87.0% (20/23), and accuracy of 90.0% (27/30), respectively. For IIM patients, 18F-FDG PET/CT has multiple values in identifying malignancies, observing the status of inflammatory myopathy, detecting interstitial lung disease, and predicting the occurrence of RP-ILD. Therefore, it is recommended to use PET/CT in the clinical course of diagnosis and management of IIM.

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Funding

This study received no funding.

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Author notes

  1. Dr. Yuan Li and Dr. Yunshan Zhou contributed equally to this work.

Authors and Affiliations

  1. Department of Nuclear Medicine, Peking University People’s Hospital, 11th Xizhimen South St., Beijing, 100044, China

    Yuan Li & Qian Wang

  2. Department of Rheumatology and Immunology, Peking University People’s Hospital, Beijing, China

    Yunshan Zhou

Authors
  1. Yuan Li
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  2. Yunshan Zhou
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  3. Qian Wang
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Corresponding author

Correspondence to Qian Wang.

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The study was performed in accordance with the tenets of the Declaration of Helsinki and was approved by the institutional review board. All patients provided written informed consent for the use of their medical reports for research.

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Li, Y., Zhou, Y. & Wang, Q. Multiple values of 18F-FDG PET/CT in idiopathic inflammatory myopathy. Clin Rheumatol 36, 2297–2305 (2017). https://doi.org/10.1007/s10067-017-3794-3

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  • DOI: https://doi.org/10.1007/s10067-017-3794-3

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