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Mixed connective tissue disease with interstitial pneumonia in HTLV-1 carrier: case report and review of the literature

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Abstract

We report on a carrier of human T-lymphotropic virus type 1 (HTLV-1) who developed mixed connective tissue disease (MCTD). This patient suddenly manifested clinical symptoms and interstitial pneumonia ascribable to MCTD following long-term infection with HTLV-1. After initiation of oral prednisolone all manifestations quickly improved in parallel with a decrease in inflammatory reactions. In this patient HTLV-1 infection might have played an important role in the pathogenesis of MCTD. Since HTLV-1 can cause adult T-cell leukemia and HTLV-1-associated myelopathy, and also collagen diseases including MCTD, careful observation is necessary even in a carrier, particularly when autoantibodies are detectable in serum.

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Authors and Affiliations

  1. Division of Rheumatology, Third Department of Medicine, Shinshu University School of Medicine, 3-1-1 Asahi, 390-8621, Matsumoto, Japan

    Yasuhiro Shimojima, Wataru Ishii, Akiyo Hineno, Kanji Yamamoto, Masayuki Matsuda & Shu-ichi Ikeda

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  1. Yasuhiro Shimojima
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  2. Wataru Ishii
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  3. Akiyo Hineno
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  4. Kanji Yamamoto
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  5. Masayuki Matsuda
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  6. Shu-ichi Ikeda
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Correspondence to Masayuki Matsuda.

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Shimojima, Y., Ishii, W., Hineno, A. et al. Mixed connective tissue disease with interstitial pneumonia in HTLV-1 carrier: case report and review of the literature. Clin Rheumatol 23, 548–551 (2004). https://doi.org/10.1007/s10067-004-0955-y

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  • DOI: https://doi.org/10.1007/s10067-004-0955-y

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