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Blutungen und Gerinnungsstörungen beim Polytrauma

Aktueller Stand der Diagnostik und des Managements bei traumaassoziierten Koagulopathien

Bleeding and coagulation disorders in polytrauma patients

Current status in the diagnosis and management of trauma-associated coagulopathy

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Zusammenfassung

Hintergrund

Unkontrollierbare Blutungen sind eine der führenden Todesursachen beim Traumapatienten.

Fragestellung

Die Entwicklungen und Empfehlungen der Akuttherapie traumatischer Blutungen sollen dargestellt werden.

Material und Methode

Übersichtsarbeit unter Berücksichtigung aktueller Studien und den 2013 überarbeiteten „European Guidelines“.

Ergebnisse

Klare Empfehlungen hinsichtlich Basis- und erweiterter Diagnostik, externer Maßnahmen und Substitution von Gerinnungs- und Blutprodukten können gegeben werden.

Schlussfolgerung

Kliniken der Traumaversorgung sollten einen individuellen, an die lokalen Gegebenheiten und internationalen Empfehlungen angelehnten Algorithmus zur Therapie der traumaassoziierten Koagulopathie vorhalten.

Abstract

Background

Uncontrolled hemorrhage is one of the leading causes of death in trauma patients.

Objective

The purpose of this article is to present and discuss current developments and recommendations regarding the acute treatment of bleeding trauma patients.

Materials and methods

A review of recent studies and the 2013 update of the European Guidelines are presented.

Results

Clear recommendations regarding basic and advanced diagnostic procedures and interventions are given.

Conclusion

Hospitals involved in trauma care should have an individual algorithm for the treatment of bleeding patients, based on international guidelines and adapted to local circumstances.

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Literatur

  1. Baraniuk S, Tilley BC, Del Junco DJ et al (2014) Pragmatic randomized optimal platelet and plasma ratios (PROPPR) trial: design, rationale and implementation. Injury 45:1287–1295

    Article  PubMed  Google Scholar 

  2. Bellamy RF (1984) The causes of death in conventional land warfare: implications for combat casualty care research. Mil Med 149:55–62

    CAS  PubMed  Google Scholar 

  3. Borgman MA, Spinella PC, Holcomb JB et al (2011) The effect of FFP: RBC ratio on morbidity and mortality in trauma patients based on transfusion prediction score. Vox Sang 101:44–54

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  4. Borgman MA, Spinella PC, Perkins JG et al (2007) The ratio of blood products transfused affects mortality in patients receiving massive transfusions at a combat support hospital. J Trauma 63:805–813

    Article  PubMed  Google Scholar 

  5. Brohi K, Cohen MJ, Davenport RA (2007) Acute coagulopathy of trauma: mechanism, identification and effect. Curr Opin Crit Care 13:680–685

    Article  PubMed  Google Scholar 

  6. Brohi K, Cohen MJ, Ganter MT et al (2007) Acute traumatic coagulopathy: initiated by hypoperfusion: modulated through the protein C pathway? Ann Surg 245:812–818

    Article  PubMed Central  PubMed  Google Scholar 

  7. Brohi K, Singh J, Heron M et al (2003) Acute traumatic coagulopathy. J Trauma 54:1127–1130

    Article  PubMed  Google Scholar 

  8. Engstrom M, Schott U, Romner B et al (2006) Acidosis impairs the coagulation: a thromboelastographic study. J Trauma 61:624–628

    Article  PubMed  Google Scholar 

  9. Esposito TJ, Sanddal ND, Hansen JD et al (1995) Analysis of preventable trauma deaths and inappropriate trauma care in a rural state. J Trauma 39:955–962

    Article  CAS  PubMed  Google Scholar 

  10. Gonzalez EA, Moore FA, Holcomb JB et al (2007) Fresh frozen plasma should be given earlier to patients requiring massive transfusion. J Trauma 62:112–119

    Article  PubMed  Google Scholar 

  11. Guyatt G, Gutterman D, Baumann MH et al (2006) Grading strength of recommendations and quality of evidence in clinical guidelines: report from an american college of chest physicians task force. Chest 129:174–181

    Article  PubMed  Google Scholar 

  12. Hauser CJ, Boffard K, Dutton R et al (2010) Results of the CONTROL trial: efficacy and safety of recombinant activated Factor VII in the management of refractory traumatic hemorrhage. J Trauma 69:489–500

    Article  CAS  PubMed  Google Scholar 

  13. Hess JR, Brohi K, Dutton RP et al (2008) The coagulopathy of trauma: a review of mechanisms. J Trauma 65:748–754

    Article  CAS  PubMed  Google Scholar 

  14. Hess JR, Dutton RB, Holcomb JB et al (2008) Giving plasma at a 1:1 ratio with red cells in resuscitation: who might benefit? Transfusion 48:1763–1765

    Article  PubMed  Google Scholar 

  15. Hess JR, Lawson JH (2006) The coagulopathy of trauma versus disseminated intravascular coagulation. J Trauma 60:S12–S19

    Article  PubMed  Google Scholar 

  16. Holcomb JB, Fox EE, Zhang X et al (2013) Cryoprecipitate use in the PROMMTT study. J Trauma Acute Care Surg 75:S31–S39

    Article  PubMed Central  Google Scholar 

  17. Holcomb JB, Wade CE, Michalek JE et al (2008) Increased plasma and platelet to red blood cell ratios improves outcome in 466 massively transfused civilian trauma patients. Ann Surg 248:447–458

    PubMed  Google Scholar 

  18. Krug EG, Sharma GK, Lozano R (2000) The global burden of injuries. Am J Public Health 90:523–526

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  19. Lier H, Kampe S, Schroder S (2007) Prerequisites of a functional haemostasis. What must be considered at the scene of an accident, in the emergency room and during an operation? Anaesthesist 56:239–251

    Article  CAS  PubMed  Google Scholar 

  20. Lier H, Krep H, Schochl H (2009) Coagulation management in the treatment of multiple trauma. Anaesthesist 58:1010–1026

    Article  CAS  PubMed  Google Scholar 

  21. Lier H, Krep H, Schroeder S et al (2008) Preconditions of hemostasis in trauma: a review. The influence of acidosis, hypocalcemia, anemia, and hypothermia on functional hemostasis in trauma. J Trauma 65:951–960

    Article  PubMed  Google Scholar 

  22. Macleod JB, Lynn M, Mckenney MG et al (2003) Early coagulopathy predicts mortality in trauma. J Trauma 55:39–44

    Article  PubMed  Google Scholar 

  23. Maegele M (2014) The coagulopathy of trauma. Eur J Trauma Emerg Surg 40:113–126

    Article  Google Scholar 

  24. Maegele M, Lefering R, Paffrath T et al (2008) Red-blood-cell to plasma ratios transfused during massive transfusion are associated with mortality in severe multiple injury: a retrospective analysis from the Trauma Registry of the Deutsche Gesellschaft fur Unfallchirurgie. Vox Sang 95:112–119

    Article  CAS  PubMed  Google Scholar 

  25. Maegele M, Lefering R, Wafaisade A et al (2010) Revalidation and update of the TASH-Score: a scoring system to predict the probability for massive transfusion as a surrogate for life-threatening haemorrhage after severe injury. Vox Sang 100:231–238

    Article  PubMed  Google Scholar 

  26. Maegele M, Lefering R, Yucel N et al (2007) Early coagulopathy in multiple injury: an analysis from the German Trauma Registry on 8724 patients. Injury 38:298–304

    Article  PubMed  Google Scholar 

  27. Maegele M, Paffrath T, Bouillon B (2012) Acute traumatic coagulopathy in severe injury: incidence, risk stratification, and treatment options. Dtsch Arztebl Int 108:827–835

    Google Scholar 

  28. Mann KG, Butenas S, Brummel K (2003) The dynamics of thrombin formation. Arterioscler Thromb Vasc Biol 23:17–25

    Article  CAS  PubMed  Google Scholar 

  29. Nunez TC, Voskresensky IV, Dossett LA et al (2009) Early prediction of massive transfusion in trauma: simple as ABC (assessment of blood consumption)? J Trauma 66:346–352

    Article  PubMed  Google Scholar 

  30. Rossaint R, Bouillon B, Cerny V et al (2013) The STOP the bleeding campaign. Crit Care 17:136

    Article  PubMed Central  PubMed  Google Scholar 

  31. Sauaia A, Moore FA, Moore EE et al (1995) Epidemiology of trauma deaths: a reassessment. J Trauma 38:185–193

    Article  CAS  PubMed  Google Scholar 

  32. Shakur H, Roberts I, Bautista R et al (2010) Effects of tranexamic acid on death, vascular occlusive events, and blood transfusion in trauma patients with significant haemorrhage (CRASH-2): a randomised, placebo-controlled trial. Lancet 376:23–32

    Article  CAS  PubMed  Google Scholar 

  33. Spahn DR, Bouillon B, Cerny V et al (2013) Management of bleeding and coagulopathy following major trauma: an updated European guideline. Crit Care 17:R76

    Article  PubMed Central  PubMed  Google Scholar 

  34. Spahn DR, Rossaint R (2005) Coagulopathy and blood component transfusion in trauma. Br J Anaesth 95:130–139

    Article  CAS  PubMed  Google Scholar 

  35. Wafaisade A, Wutzler S, Lefering R et al (2010) Drivers of acute coagulopathy after severe trauma: a multivariate analysis of 1987 patients. Emerg Med J 27:934–939

    Article  PubMed  Google Scholar 

  36. Weber CF, Adam EH, Meybohm P et al (2013) Management of extended blood loss and massive transfusion. Anasthesiol Intensivmed Notfallmed Schmerzther 48:314–317

    Article  PubMed  Google Scholar 

  37. Yucel N, Lefering R, Maegele M et al (2006) Trauma Associated Severe Hemorrhage (TASH)-score: probability of mass transfusion as surrogate for life threatening hemorrhage after multiple trauma. J Trauma 60:1228–1236

    Article  PubMed  Google Scholar 

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Einhaltung der ethischen Richtlinien

Interessenkonflikt. S. Wutzler, M. Maegele, T. Lustenberger, F. Hildebrand, R. Lefering, M. Frink und I. Marzi geben an, dass kein Interessenkonflikt besteht. Dieser Beitrag beinhaltet keine Studien an Menschen oder Tieren.

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Wutzler, S., Maegele, M., Lustenberger, T. et al. Blutungen und Gerinnungsstörungen beim Polytrauma. Notfall Rettungsmed 17, 567–574 (2014). https://doi.org/10.1007/s10049-014-1863-6

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  • DOI: https://doi.org/10.1007/s10049-014-1863-6

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